PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Serum Calcium Levels Approaching the Upper Limit of Normal Can Predict Prostate Cancer Relapse to the Bone and Beyond in Patients Managed with Radiotherapy: Mature Data at 10 Years
Version 1
: Received: 22 April 2024 / Approved: 23 April 2024 / Online: 25 April 2024 (08:39:04 CEST)
How to cite:
Fekete, Z.; Ignat, P.; Jakab, H.; Todor, N.; László, I.P.; Muntean, A.; Curcean, S.; Nemeș, A.; Nuțu, D.; Kacsó, G. Serum Calcium Levels Approaching the Upper Limit of Normal Can Predict Prostate Cancer Relapse to the Bone and Beyond in Patients Managed with Radiotherapy: Mature Data at 10 Years. Preprints2024, 2024041558. https://doi.org/10.20944/preprints202404.1558.v1
Fekete, Z.; Ignat, P.; Jakab, H.; Todor, N.; László, I.P.; Muntean, A.; Curcean, S.; Nemeș, A.; Nuțu, D.; Kacsó, G. Serum Calcium Levels Approaching the Upper Limit of Normal Can Predict Prostate Cancer Relapse to the Bone and Beyond in Patients Managed with Radiotherapy: Mature Data at 10 Years. Preprints 2024, 2024041558. https://doi.org/10.20944/preprints202404.1558.v1
Fekete, Z.; Ignat, P.; Jakab, H.; Todor, N.; László, I.P.; Muntean, A.; Curcean, S.; Nemeș, A.; Nuțu, D.; Kacsó, G. Serum Calcium Levels Approaching the Upper Limit of Normal Can Predict Prostate Cancer Relapse to the Bone and Beyond in Patients Managed with Radiotherapy: Mature Data at 10 Years. Preprints2024, 2024041558. https://doi.org/10.20944/preprints202404.1558.v1
APA Style
Fekete, Z., Ignat, P., Jakab, H., Todor, N., László, I.P., Muntean, A., Curcean, S., Nemeș, A., Nuțu, D., & Kacsó, G. (2024). Serum Calcium Levels Approaching the Upper Limit of Normal Can Predict Prostate Cancer Relapse to the Bone and Beyond in Patients Managed with Radiotherapy: Mature Data at 10 Years. Preprints. https://doi.org/10.20944/preprints202404.1558.v1
Chicago/Turabian Style
Fekete, Z., Dumitrița Nuțu and Gabriel Kacsó. 2024 "Serum Calcium Levels Approaching the Upper Limit of Normal Can Predict Prostate Cancer Relapse to the Bone and Beyond in Patients Managed with Radiotherapy: Mature Data at 10 Years" Preprints. https://doi.org/10.20944/preprints202404.1558.v1
Abstract
The most important prognostic factors in curatively treated prostate cancer at the initial diagnosis are T and N stage, histological subtype, Gleason score, initial PSA, PSA density and percentage of core biopsy positivity. Newer, but non-standard prognostic factors are urine PCA3 and genetic markers of prostate cancer. A simple, but seemingly underestimated standard test is serum Calcium (Ca) level, which has been shown by a previous study group to be a good predictor of lethal prostate cancer, but there is scarce evidence regarding the prognostic value of calcium levels at diagnosis. We aimed to determine whether a Ca level in the upper part of normal values has a prognostic value in curatively treated prostate cancer. We have retrospectively included 84 consecutive patients with prostate cancer, who underwent curative radiotherapy (primary or adjuvant; external beam RT with or without brachytherapy). We have performed statistical analysis of available prognostic factors. Ca level at diagnosis was found to be a statistically significant predictor of disease-free survival.
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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