Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Alkaloid Profiling and Anti-Cholinesterase Potential of Three Different Genera of Amaryllidaceae Collected in Ecuador: Urceolina Rchb., Clinanthus Herb., and Stenomesson Herb

Luciana R. Tallini
ORCID logo ,
Karen Acosta León
,
Raúl Chamorro
,
Edison H. Osorio
ORCID logo ,
Jaume Bastida
,
Lou Jost
,
Nora H. Oleas
*
Version 1 : Received: 8 April 2024 / Approved: 8 April 2024 / Online: 9 April 2024 (07:40:34 CEST)

How to cite: Tallini, L.R.; Acosta León, K.; Chamorro, R.; Osorio, E.H.; Bastida, J.; Jost, L.; Oleas, N.H. Alkaloid Profiling and Anti-Cholinesterase Potential of Three Different Genera of Amaryllidaceae Collected in Ecuador: Urceolina Rchb., Clinanthus Herb., and Stenomesson Herb. Preprints 2024, 2024040592. https://doi.org/10.20944/preprints202404.0592.v1 Tallini, L.R.; Acosta León, K.; Chamorro, R.; Osorio, E.H.; Bastida, J.; Jost, L.; Oleas, N.H. Alkaloid Profiling and Anti-Cholinesterase Potential of Three Different Genera of Amaryllidaceae Collected in Ecuador: Urceolina Rchb., Clinanthus Herb., and Stenomesson Herb. Preprints 2024, 2024040592. https://doi.org/10.20944/preprints202404.0592.v1

Abstract

Ecuador is an important center of biodiversity of the plant family Amaryllidaceae, specially the subfamily Amaryllidoideae, known as a source of important bioactive molecules. The aim of this study was to assess the chemical and biological potential of four different species of Amaryllidoideae collected in Ecuador: Urceolina formosa, Urceolina ruthiana, Clinanthus incarnatus, and Stenomesson aurantiacum. Sixteen alkaloids were identified in the bulb extract of these species by GC-MS, which the extract of S. aurantiacum exhibiting the greatest structural diversity. The potential of these three genera against Alzheimer’s disease was evaluated by measuring their AChE and BuChE inhibitory activity, revealing that C. incarnatus and U. formosa (from Sucumbíos province) showed the best results with IC50 values of 1.73 ± 0.25 and 30.56 ± 1.56 g·ml-1, respectively. Molecular dynamic assays were conducted to elucidate the possible interactions that occurs among 2-hydroxyanhydrolycorine and AChE enzyme, suggesting some similarity with those observed for galanthamine. This study enhances our understanding of the biodiversity of Amaryllidoideae species from Ecuador, highlighting their potential as a source of chemical compounds with pharmaceutical potential.

Keywords

Amaryllidoideae; alkaloids; Amazon lily; Alzheimer’s disease; computational experiments

Subject

Medicine and Pharmacology, Pharmacology and Toxicology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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