Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Urinary L-FABP as an Early Biomarker for Pediatric Acute Kidney Injury Following Cardiac Surgery with Cardiopulmonary Bypass: A Systematic Review and Meta-analysis

Version 1 : Received: 1 April 2024 / Approved: 2 April 2024 / Online: 2 April 2024 (09:03:57 CEST)

How to cite: Wilnes, B.; Castello-Branco, B.; Castello Branco, B.; Sanglard, A.; Vaz de Castro, P.A.S.; Simões e Silva, A.C. Urinary L-FABP as an Early Biomarker for Pediatric Acute Kidney Injury Following Cardiac Surgery with Cardiopulmonary Bypass: A Systematic Review and Meta-analysis. Preprints 2024, 2024040155. https://doi.org/10.20944/preprints202404.0155.v1 Wilnes, B.; Castello-Branco, B.; Castello Branco, B.; Sanglard, A.; Vaz de Castro, P.A.S.; Simões e Silva, A.C. Urinary L-FABP as an Early Biomarker for Pediatric Acute Kidney Injury Following Cardiac Surgery with Cardiopulmonary Bypass: A Systematic Review and Meta-analysis. Preprints 2024, 2024040155. https://doi.org/10.20944/preprints202404.0155.v1

Abstract

Acute kidney injury (AKI) following surgery with cardiopulmonary bypass (CPB-AKI) is common in pediatrics. Urinary liver-type fatty acid binding protein (uL-FABP) increases in some kidney diseases and may indicate CPB-AKI earlier than current methods. The aim of this systematic review with meta-analysis was to evaluate the potential role of uL-FABP in early predicting CPB-AKI. Databases Pubmed/MEDLINE, Scopus, and Web of Science were searched on November 12th, 2023, using the MeSH terms “Children”, “CPB”, “L-FABP”, and “Acute Kidney Injury”. Included papers were revised. AUC values from similar studies were pooled by meta-analysis, performed using random- and fixed-effect models, with p

Keywords

acute kidney injury; cardiac surgery; pediatrics; cardiopulmonary bypass; biomarkers; Liver-type Fatty Acid-binding Protein

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.