Oishi, T.; Yasui, Y.; Kato, A.; Ogita, S.; Eitoku, T.; Enoki, H.; Nakano, T. Analysis of Cell Immunity for Children Infected with SARS-CoV-2 and Those Vaccinated against SARS-CoV-2 Using T-SPOT®.COVID. Microorganisms2024, 12, 975.
Oishi, T.; Yasui, Y.; Kato, A.; Ogita, S.; Eitoku, T.; Enoki, H.; Nakano, T. Analysis of Cell Immunity for Children Infected with SARS-CoV-2 and Those Vaccinated against SARS-CoV-2 Using T-SPOT®.COVID. Microorganisms 2024, 12, 975.
Oishi, T.; Yasui, Y.; Kato, A.; Ogita, S.; Eitoku, T.; Enoki, H.; Nakano, T. Analysis of Cell Immunity for Children Infected with SARS-CoV-2 and Those Vaccinated against SARS-CoV-2 Using T-SPOT®.COVID. Microorganisms2024, 12, 975.
Oishi, T.; Yasui, Y.; Kato, A.; Ogita, S.; Eitoku, T.; Enoki, H.; Nakano, T. Analysis of Cell Immunity for Children Infected with SARS-CoV-2 and Those Vaccinated against SARS-CoV-2 Using T-SPOT®.COVID. Microorganisms 2024, 12, 975.
Abstract
To elucidate the cellular immune response to coronavirus disease (COVID-19) among children, we assessed cellular immunity in 8 children post-vaccination for COVID-19 and 11 children after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, using the T-SPOT®.COVID assay for both the spike (S) and nucleocapsid (N) proteins. In the vaccinated group, the T-SPOT®.COVID assay for the S protein yielded positive results in all eight children. In contrast, in the post-infection group, the assay for the N protein was positive in 5 of 11 children, with 3 of these 5 children requiring hospital admission, including 2 who needed mechanical ventilation. Therefore, the T-SPOT®.COVID assay is valuable for assessing cellular immunity against COVID-19, and most children infected with COVID-19 may not develop such immunity unless the disease severity is significant.
Keywords
cell immunity; COVID-19; children; T-Spot®
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
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