Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

m6A Methylation in Regulation of Antiviral Innate Immunity

Ivan Karandashov
ORCID logo ,
Anastasiya Kostyusheva
,
Artyom Kachanov
,
Maria Dukich
,
Natalia Ponomareva
,
Sergey Brezgin
ORCID logo ,
Alexander Lukashev
,
Vadim S Pokrovsky
,
Vladimir Chulanov
ORCID logo ,
Dmitry Kostyushev
* ORCID logo
Version 1 : Received: 14 March 2024 / Approved: 14 March 2024 / Online: 14 March 2024 (11:02:10 CET)

A peer-reviewed article of this Preprint also exists.

Karandashov, I.; Kachanov, A.; Dukich, M.; Ponomareva, N.; Brezgin, S.; Lukashev, A.; Pokrovsky, V.S.; Chulanov, V.; Kostyusheva, A.; Kostyushev, D. m6A Methylation in Regulation of Antiviral Innate Immunity. Viruses 2024, 16, 601. Karandashov, I.; Kachanov, A.; Dukich, M.; Ponomareva, N.; Brezgin, S.; Lukashev, A.; Pokrovsky, V.S.; Chulanov, V.; Kostyusheva, A.; Kostyushev, D. m6A Methylation in Regulation of Antiviral Innate Immunity. Viruses 2024, 16, 601.

Abstract

The epitranscriptomic modification m6A is a prevalent RNA modification that plays a crucial role in the regulation of various aspects of RNA metabolism. It has been found to be involved in a wide range of physiological processes and disease states. Of particular interest is the role of m6A machinery and modifications in viral infections, serving as an evolutionary marker for distinguishing between self and non-self entities. In this review article, we present a comprehensive overview of the epitranscriptomic modification m6A and its implications in the interplay between viruses and their host, focusing on immune responses and viral replication. We outline future research directions that highlight the role of m6A in viral nucleic acid recognition, initiation of antiviral immune responses, and modulation of antiviral signaling pathways. Additionally, we discuss the potential of m6A as a prognostic biomarker and a target for therapeutic interventions in viral infections.

Keywords

TLR; RLR; herpesviruses; hepatitis viruses; coronaviruses; retroviruses; flaviviruses; adenoviruses

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.