Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

SIRT1 Serum Concentrations in Lipodystrophic Syndromes

Luisa Salvatori
,
Giovanni Ceccarini
ORCID logo ,
Silvia Magno
ORCID logo ,
Rossella Tozzi
ORCID logo ,
Savina Contini
,
Caterina Pelosini
,
Ferruccio Santini
,
Lucio Gnessi
,
Stefania Mariani
* ORCID logo
Version 1 : Received: 12 March 2024 / Approved: 13 March 2024 / Online: 13 March 2024 (09:53:54 CET)

How to cite: Salvatori, L.; Ceccarini, G.; Magno, S.; Tozzi, R.; Contini, S.; Pelosini, C.; Santini, F.; Gnessi, L.; Mariani, S. SIRT1 Serum Concentrations in Lipodystrophic Syndromes. Preprints 2024, 2024030770. https://doi.org/10.20944/preprints202403.0770.v1 Salvatori, L.; Ceccarini, G.; Magno, S.; Tozzi, R.; Contini, S.; Pelosini, C.; Santini, F.; Gnessi, L.; Mariani, S. SIRT1 Serum Concentrations in Lipodystrophic Syndromes. Preprints 2024, 2024030770. https://doi.org/10.20944/preprints202403.0770.v1

Abstract

Abstract: Lipodystrophies (LDs) are rare, complex disorders of the adipose tissue characterized by selective fat loss, altered adipokines profile and metabolic impairment. Sirtuins (SIRTs) are class III NAD+-dependent histone-deacetylases linked to fat metabolism. SIRT1 plays a critical role in metabolic health by deacetylating target proteins in tissues including liver, muscle and adipose tissue. Circulating SIRT1 levels have been found to be reduced in obesity while increased in anorexia nervosa and in patients experiencing weight loss. We evaluated circulating SIRT1 levels in relation to fat amount in 32 lipodystrophic patients affected by congenital or acquired LDs compared to non-LD subjects (24 with anorexia nervosa, 22 normal weight and 24 with obe-sity). SIRT1 serum levels were higher in LDs as compared with normal weight subjects (mean ± SEM: 4.17 ± 0.48 vs. 2.59 ± 0.20 ng/mL) or subjects with obesity (1.7 ± 0.39 ng/mL), whereas they were close to those measured in anorexia nervosa (3.44 ± 0.46 ng/mL). Our findings show that within the LD group there was no relationship between SIRT1 levels and the amount of body fat. The mechanisms responsible for secretion and regulation of SIRT1 in LD deserve further investi-gation.

Keywords

Keywords: Lipodystrophy syndromes; SIRT1; adipose tissue; adipokines

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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