Review
Version 1
Preserved in Portico This version is not peer-reviewed
Nano‐Delivery Systems for Curcumin
Version 1
: Received: 7 March 2024 / Approved: 8 March 2024 / Online: 8 March 2024 (16:40:22 CET)
How to cite: Yakubu, J.; Pandey, A.V. Nano‐Delivery Systems for Curcumin. Preprints 2024, 2024030540. https://doi.org/10.20944/preprints202403.0540.v1 Yakubu, J.; Pandey, A.V. Nano‐Delivery Systems for Curcumin. Preprints 2024, 2024030540. https://doi.org/10.20944/preprints202403.0540.v1
Abstract
Curcumin, a polyphenol with a rich history spanning two centuries, has emerged as a promising therapeutic agent targeting multiple signaling pathways and exhibiting cellular-level activities that contribute to its diverse health benefits. Extensive preclinical and clinical studies have demonstrated its ability to enhance the therapeutic potential of various bioactive compounds. While its reported therapeutic advantages are manifold, predominantly attributed to its antioxidant and anti-inflammatory properties, its efficacy is hindered by poor bioavailability stemming from inadequate absorption, rapid metabolism, and elimination. To address this challenge, nano-delivery systems have emerged as a promising approach, offering enhanced solubility, biocompatibility, and therapeutic effects for curcumin. We have analyzed the knowledge on curcumin nano-encapsulation and its synergistic effects with other compounds, extracted from electronic databases. We discuss the pharmacokinetic profile of curcumin, current advancements in nano-encapsulation techniques, and the combined effects of curcumin with other agents across various disorders. By unifying existing knowledge, this analysis intends to provide insights into the potential of nano-encapsulation technologies to overcome constraints associated with curcumin treatments, emphasizing the importance of combinatorial approaches in improving therapeutic efficacy. Finally, this compilation of study data aims to inform and inspire future research into encapsulating drugs with poor pharmacokinetic characteristics and investigating innovative drug combinations to improve bioavailability and therapeutic outcomes.
Keywords
Curcumin; curcuminoids; nanoparticles; nanomedicine; nano-encapsulation; nano-delivery.
Subject
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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