Version 1
: Received: 5 March 2024 / Approved: 6 March 2024 / Online: 6 March 2024 (13:07:01 CET)
How to cite:
Sukorini, U.; Puspitawati, I.; Wardhani, Y.; Munajih, M.R. The Role of Thromboelastography as a Predictor of Acute Kidney Injury in COVID-19 Patients in ICU. Preprints2024, 2024030347. https://doi.org/10.20944/preprints202403.0347.v1
Sukorini, U.; Puspitawati, I.; Wardhani, Y.; Munajih, M.R. The Role of Thromboelastography as a Predictor of Acute Kidney Injury in COVID-19 Patients in ICU. Preprints 2024, 2024030347. https://doi.org/10.20944/preprints202403.0347.v1
Sukorini, U.; Puspitawati, I.; Wardhani, Y.; Munajih, M.R. The Role of Thromboelastography as a Predictor of Acute Kidney Injury in COVID-19 Patients in ICU. Preprints2024, 2024030347. https://doi.org/10.20944/preprints202403.0347.v1
APA Style
Sukorini, U., Puspitawati, I., Wardhani, Y., & Munajih, M.R. (2024). The Role of Thromboelastography as a Predictor of Acute Kidney Injury in COVID-19 Patients in ICU. Preprints. https://doi.org/10.20944/preprints202403.0347.v1
Chicago/Turabian Style
Sukorini, U., Yulia Wardhani and Muhammad Roihan Munajih. 2024 "The Role of Thromboelastography as a Predictor of Acute Kidney Injury in COVID-19 Patients in ICU" Preprints. https://doi.org/10.20944/preprints202403.0347.v1
Abstract
There is evidence that kidney involvement is frequently observed in COVID-19 patients, and can manifest as mild proteinuria to advancing acute kidney injury (AKI). One of the mechanisms is microvascular and macrovascular thrombosis caused by the hypercoagulation phase of the disease. Thromboelastography (TEG) is a valuable examination to detect significant hemostatic abnormalities, including the hypercoagulable state. This study analyzed the coagulation profiles, including TEG parameters, in COVID-19 patients who developed AKI compared to those who did not during their intensive care unit (ICU) stay, to identify predictors of AKI. Our single-center cohort retrospective study involved adult patients of COVID-19 in the ICU of Sardjito Hospital in Yogyakarta, Indonesia between May and September 2021. Patients were divided into two groups of AKI and non-AKI based on 2012 KDIGO definition and the elaboration by Indonesian Society of Nephrology. Variables showing a significant difference in the two groups were then analyzed using univariate and multivariate binary logistic regression. A total of 60 COVID-19 patients were included in the study, and 35% of them developed AKI. Compared to non-AKI patients, those with AKI exhibited a greater prevalence of diabetes mellitus (66.7% versus 35.9%, P = 0.023), higher D-Dimer levels (970 versus 685 ng/mL, P = 0.045), and higher values in TEG parameters of maximum amplitude/MA (74.6 versus 65.9 mm, P = 0.001) and coagulation index/CI (2.3 versus 1.0, P = 0.033). TEG parameter of MA emerged as the sole significant predictor for the development of AKI (OR, 6.33; 95% CI, 1.56 to 25.64). Our study validated the kidney involvement of COVID-19 infection, and showed that diabetes mellitus, high D-Dimer levels, and hypercoagulability serve as prominent risk factors in the development of AKI. Furthermore, TEG parameter of MA exceeding 70 mm is the single independent significant predictor of AKI.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
