Version 1
: Received: 4 March 2024 / Approved: 4 March 2024 / Online: 5 March 2024 (10:20:20 CET)
How to cite:
Bo, Y.; Lu, Q.; Li, B.; He, J.; Miao, C. The Role of Platelets in Central Hubs of Inflammation: A literature review. Preprints2024, 2024030253. https://doi.org/10.20944/preprints202403.0253.v1
Bo, Y.; Lu, Q.; Li, B.; He, J.; Miao, C. The Role of Platelets in Central Hubs of Inflammation: A literature review. Preprints 2024, 2024030253. https://doi.org/10.20944/preprints202403.0253.v1
Bo, Y.; Lu, Q.; Li, B.; He, J.; Miao, C. The Role of Platelets in Central Hubs of Inflammation: A literature review. Preprints2024, 2024030253. https://doi.org/10.20944/preprints202403.0253.v1
APA Style
Bo, Y., Lu, Q., Li, B., He, J., & Miao, C. (2024). The Role of Platelets in Central Hubs of Inflammation: A literature review. Preprints. https://doi.org/10.20944/preprints202403.0253.v1
Chicago/Turabian Style
Bo, Y., Jianxun He and Chuhan Miao. 2024 "The Role of Platelets in Central Hubs of Inflammation: A literature review" Preprints. https://doi.org/10.20944/preprints202403.0253.v1
Abstract
Background: Platelets are increasingly recognised for their multifaceted roles in inflammation beyond their traditional involvement in haemostasis. This review consolidates knowledge on platelets as critical players in inflammatory responses. Methods: This study did an extensive search of electronic databases and identified studies on platelets in inflammation, focusing on molecular mechanisms, cell interactions, and clinical implications, emphasising recent publications. Results: Platelets contribute to inflammation via surface receptors, release of mediators, and participation in neutrophil extracellular trap formation. They are implicated in diseases like atherosclerosis, rheumatoid arthritis, and sepsis, highlighting their interaction with immune cells as pivotal in the onset and resolution of inflammation. Conclusion: Platelets are central to regulating inflammation, offering new therapeutic targets for inflammatory diseases. Future research should explore specific molecular pathways of platelets in inflammation for therapeutic intervention.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
