Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Infectious Diseases and Secondary Antibody Deficiency in Patients from a Mesoregion of São Paulo State

Luiz Euribel Prestes-Carneiro
* ORCID logo ,
Paula Andreia Martins Carrilho
,
Danimelle Francisco Honorato de Barros Torelli
,
Jose Antonio Nascimento Bressa
,
Ana Carolina Gomes Parizi
,
Pedro Henrique Meirelles Vieira
,
Fernanda Miranda Caliani Sa
,
Mauricio Domingues Ferreira
Version 1 : Received: 1 March 2024 / Approved: 4 March 2024 / Online: 4 March 2024 (15:50:34 CET)

How to cite: Prestes-Carneiro, L.E.; Martins Carrilho, P.A.; Honorato de Barros Torelli, D.F.; Nascimento Bressa, J.A.; Gomes Parizi, A.C.; Meirelles Vieira, P.H.; Caliani Sa, F.M.; Domingues Ferreira, M. Infectious Diseases and Secondary Antibody Deficiency in Patients from a Mesoregion of São Paulo State. Preprints 2024, 2024030166. https://doi.org/10.20944/preprints202403.0166.v1 Prestes-Carneiro, L.E.; Martins Carrilho, P.A.; Honorato de Barros Torelli, D.F.; Nascimento Bressa, J.A.; Gomes Parizi, A.C.; Meirelles Vieira, P.H.; Caliani Sa, F.M.; Domingues Ferreira, M. Infectious Diseases and Secondary Antibody Deficiency in Patients from a Mesoregion of São Paulo State. Preprints 2024, 2024030166. https://doi.org/10.20944/preprints202403.0166.v1

Abstract

Our aim was to determine the secondary antibody deficiency profiles of patients in a mesoregion of São Paulo state, Brazil, focusing on infectious diseases. Demographic characteristics, clinical and laboratory data were obtained from electronic files; infections were classified as organ-specific and graded as mild, moderate, life-threatening, and fatal. Non-Hodgkin lymphoma (NHL) accounted for 30% of patients, nephrotic syndrome (NS) 25%; chronic lymphocyte leukemia 20%, and multiple myeloma 15%. Patients with NS were younger than those in other groups, and hypo-γ-globulinemia was detected in 94.1%, IgG <400 mg/dL in 60.0%, IgA <40 mg/dL in 55.0%, and CD19 <20 cells/mm3 in 30.0%. One hundred and one infections were found; 82.1% were classified as mild or moderate, 7.9% as life-threatening, and 1.9% as fatal. Respiratory tract infections were more prevalent (41.5%), and pneumonia accounted for 19.8%. Lower levels of infections were found in patients with NS compared with NHL (P=0.0001). Most patients progressed to hypo-γ-globulinemia and secondary antibody deficiency after treatment with immunosuppressants, and mild and moderate infections were predominant. These therapies are increasing in patients with different diseases, therefore monitoring hypo-γ-globulinemia and infections may help to identify patients at high risk for severe complications, antibiotic prophylaxis or treatment, and immunoglobulin replacement

Keywords

Secondary Antibody Deficiency; hypo-γ-globulinemia; infectious diseases 

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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