Version 1
: Received: 1 March 2024 / Approved: 1 March 2024 / Online: 3 March 2024 (18:18:41 CET)
How to cite:
Özdoğan, R.; Çakır, M.O.; Ashrafi, G.H.; Bilge, U. Diversity of HPV 16 L1 in the Asian Region: A Comparative Analysis of Sequences. Preprints2024, 2024030074. https://doi.org/10.20944/preprints202403.0074.v1
Özdoğan, R.; Çakır, M.O.; Ashrafi, G.H.; Bilge, U. Diversity of HPV 16 L1 in the Asian Region: A Comparative Analysis of Sequences. Preprints 2024, 2024030074. https://doi.org/10.20944/preprints202403.0074.v1
Özdoğan, R.; Çakır, M.O.; Ashrafi, G.H.; Bilge, U. Diversity of HPV 16 L1 in the Asian Region: A Comparative Analysis of Sequences. Preprints2024, 2024030074. https://doi.org/10.20944/preprints202403.0074.v1
APA Style
Özdoğan, R., Çakır, M.O., Ashrafi, G.H., & Bilge, U. (2024). Diversity of HPV 16 L1 in the Asian Region: A Comparative Analysis of Sequences. Preprints. https://doi.org/10.20944/preprints202403.0074.v1
Chicago/Turabian Style
Özdoğan, R., G Hossein Ashrafi and Uğur Bilge. 2024 "Diversity of HPV 16 L1 in the Asian Region: A Comparative Analysis of Sequences" Preprints. https://doi.org/10.20944/preprints202403.0074.v1
Abstract
It has been shown that Human papillomavirus (HPV) infection is associated with several forms of cancer. Additionally, although there are more than 100 types of HPV, more than ten types of it, including types 16 and 18, are considered high-risk. The two proteins that make up the viral capsid of HPV 16 are L1, the major capsid protein, and L2, the minor capsid protein. FDA (The Food and Drug Administration) approved HPV vaccines mostly target L1 and L2 capsid proteins, which facilitate intracellular entry during infection. In this study, it was set out to analyze the creation of phylogenetic relations of L1 nucleic acid sequences of viral isolates. This study also analyzed sequences of three key elements within the amino acid sequences of HPV 16 L1: loops critical for structural stability, nuclear localization signal sequences, and residues implicated in viral attachment. As highlighted by the literature, these elements represent pivotal aspects of viral function. Furthermore, the report highlighted the particular inter-sequence variability within the HPV 16 L1 protein sequences. Overall analysis revealed clustering of sequences primarily due to geographical and characterized by more phylogenetic relatedness within location-specific clusters.
Keywords
Human Papillomavirus, HPV 16, L1, Phylogenetic analysis
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
