Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Clinical Outcome Features for Non-HIV Kaposi’s Sarcoma and the Role for Surgical Wide Excision on Survival: A Retrospective Cohort Study

Version 1 : Received: 26 February 2024 / Approved: 27 February 2024 / Online: 27 February 2024 (12:23:02 CET)

How to cite: Hsu, C.; Hsu, F.; Chen, H.; Chang, C. The Clinical Outcome Features for Non-HIV Kaposi’s Sarcoma and the Role for Surgical Wide Excision on Survival: A Retrospective Cohort Study. Preprints 2024, 2024021531. https://doi.org/10.20944/preprints202402.1531.v1 Hsu, C.; Hsu, F.; Chen, H.; Chang, C. The Clinical Outcome Features for Non-HIV Kaposi’s Sarcoma and the Role for Surgical Wide Excision on Survival: A Retrospective Cohort Study. Preprints 2024, 2024021531. https://doi.org/10.20944/preprints202402.1531.v1

Abstract

In a single-center, retrospective study, 22 cases were enrolled and divided into two groups: those who underwent surgical wide excision (group A) and those who did not (group B). The study included 13 cases in group A and 9 cases in group B. In group A, 6 cases solely underwent surgical wide excision, while 7 cases received additional treatments like radiotherapy or chemotherapy. Conversely, in group B, 4 cases received chemotherapy, 4 cases received radiotherapy, and 1 case was managed through observation alone. The mean follow-up time was 60.15 months in group A and 43.44 months in group B, with no significant difference observed. In group A, 9 cases resulted in mortality, whereas 6 cases died within the follow-up period in group B. Lesion-free intervals post-operation were observed predominantly in group A, while 7 cases in group B never experienced freedom from skin lesions. Kaplan-Meier survival curve analysis demonstrated a significant difference between the survival curves of the two groups (P = 0.046). Among non-HIV Kaposi’s sarcoma patients, surgical wide excision appears to have a role in treatment. Patients in group A exhibit a more favorable outcome in the survival curve analysis.

Keywords

Kaposi’s sarcoma; non-HIV; surgery; non-surgical procedures

Subject

Medicine and Pharmacology, Clinical Medicine

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