Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Incident Cancer Risk of Patients With Prevalent Type 2 Diabetes Mellitus in Hungary (Part 2)

Zsolt Abonyi-Tóth
ORCID logo ,
György Rokszin
,
Gábor Sütő
,
Ibolya Fábián
,
Zoltán Kiss
,
György Jermendy
ORCID logo ,
Péter Kempler
,
Csaba Lengyel
,
István Wittmann
* ORCID logo ,
Gergő A. Molnár
ORCID logo
Version 1 : Received: 16 February 2024 / Approved: 20 February 2024 / Online: 20 February 2024 (07:04:22 CET)

How to cite: Abonyi-Tóth, Z.; Rokszin, G.; Sütő, G.; Fábián, I.; Kiss, Z.; Jermendy, G.; Kempler, P.; Lengyel, C.; Wittmann, I.; Molnár, G.A. Incident Cancer Risk of Patients With Prevalent Type 2 Diabetes Mellitus in Hungary (Part 2). Preprints 2024, 2024021095. https://doi.org/10.20944/preprints202402.1095.v1 Abonyi-Tóth, Z.; Rokszin, G.; Sütő, G.; Fábián, I.; Kiss, Z.; Jermendy, G.; Kempler, P.; Lengyel, C.; Wittmann, I.; Molnár, G.A. Incident Cancer Risk of Patients With Prevalent Type 2 Diabetes Mellitus in Hungary (Part 2). Preprints 2024, 2024021095. https://doi.org/10.20944/preprints202402.1095.v1

Abstract

(1) Background: Among the chronic complications of type 2 diabetes mellitus, cancer became the leading cause of death in several countries. Our objective was the determination of whether prevalent type 2 diabetes mellitus is associated with a higher incidence of cancer. (2) Methods: This study is a nationwide analysis performed in Hungary. Study population was divided into a group with type 2 diabetes mellitus and into a non-diabetic group. The primary outcome was the risk related to overall cancer incidence. A key secondary outcome was the overall incidence of cancer in distinct study years. Further outcomes were the annual percent changes. (3) Results: The odds ratio related to the overall incidence of cancer was 2.50 (95% confidence interval: 2.46-2.55, P<0.0001) in patients with diabetes as related to controls. The odds ratio was higher in males than in females. The highest risk was found in the 18-39-year-old subgroup. The annual cancer incidence rate declined in controls, but not in patients with diabetes. Several types of cancer showed a decreasing tendency in non-diabetic controls.; (4) Conclusions: type 2 diabetes is associated with a higher risk of cancer. High risk in young patients with type 2 diabetes suggests that these young individuals should be considered as a risk group.

Keywords

Diabetes mellitus (Type 2); cancer; incidence; epidemiology; age; odds ratio; annual percent change

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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