Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

ARFI of the Liver and of the Spleen, Combined with Spleen Dimension and Platelet Count in New Ratio Scores, Identifies Cirrhotic Patients with High-Risk Oesophageal Varices

Antonio F.M. Vainieri
,
Elisa Brando
,
Antonio De Vincentis
,
Giulia Di Pasquale
,
Valentina Flagiello
,
Paolo Gallo
,
Francesca Barone
,
Teresa Massaro Cenere
,
Evelyn Di Matteo
,
Antonio Picardi
,
Giovanni Galati
* ORCID logo ,
Claudia Altamura
ORCID logo ,
Carlo Altomare
,
Paola Balestrieri
,
Myriam Carpenito
,
Livio Cortese
,
Fabio Costa
ORCID logo ,
Alessandro Ferrini
,
Daria Maggi
,
Diana Lelli
,
Antonella Grasso
,
Simona Mega
,
Giuseppina Pacella
ORCID logo ,
Andrea Palermo
,
Claudia L. Piccolo
,
Simone Scarlata
,
Lorenzo Schiavoni
ORCID logo ,
Serena Stigliano
Version 1 : Received: 18 February 2024 / Approved: 18 February 2024 / Online: 19 February 2024 (14:51:45 CET)

A peer-reviewed article of this Preprint also exists.

Vainieri, A.F.M.; Brando, E.; De Vincentis, A.; Di Pasquale, G.; Flagiello, V.; Gallo, P.; Barone, F.; Massaro Cenere, T.; Di Matteo, E.; Picardi, A.; Galati, G. Acoustic Radiation Forced Impulse of the Liver and the Spleen, Combined with Spleen Dimension and Platelet Count in New Ratio Scores, Identifies High-Risk Esophageal Varices in Well-Compensated Cirrhotic Patients. Diagnostics 2024, 14, 685. Vainieri, A.F.M.; Brando, E.; De Vincentis, A.; Di Pasquale, G.; Flagiello, V.; Gallo, P.; Barone, F.; Massaro Cenere, T.; Di Matteo, E.; Picardi, A.; Galati, G. Acoustic Radiation Forced Impulse of the Liver and the Spleen, Combined with Spleen Dimension and Platelet Count in New Ratio Scores, Identifies High-Risk Esophageal Varices in Well-Compensated Cirrhotic Patients. Diagnostics 2024, 14, 685.

Abstract

Acoustic Radiation Forced Impulse (ARFI) is an ultrasound integrated method, measuring stiff-ness by point shear wave elastography. To evaluate the diagnostic performance of ARFI of the liver and of the spleen, combined with spleen dimension and platelet count, in predicting clinical events in cirrhosis, a prospective and cross-sectional study was conducted between February 2017 and February 2021. The following ratio scores with ARFI measurements were performed: ALSDP (ARFI Liver-Spleen Diameter-to-Platelets ratio score), ASSDP (ARFI Spleen-Spleen Diam-eter-to-Platelets ratio score), ASSAP (ARFI Spleen-Spleen Area-to-Platelets ratio score), ALSAP (ARFI Liver-Spleen Area-to-Platelets ratio score). In 100 enrolled subjects, spleen ARFI, ASSDP, ASSAP, were significantly associated with high-risk oesophageal varices (HRVs) in the prospec-tive short- and long-term follow-up and in the cross-sectional study (p 0.7). ARFI-ratio scores can predict, in cirrhotic patients, the risk of developing HVRs in short and long-term period.

Keywords

ARFI; acoustic radiation forced impulse; platelet count; spleen; oesophageal varices

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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