Colletti, A.; Procchio, C.; Pisano, M.; Martelli, A.; Pellizzato, M.; Cravotto, G. An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study. Nutrients2024, 16, 784.
Colletti, A.; Procchio, C.; Pisano, M.; Martelli, A.; Pellizzato, M.; Cravotto, G. An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study. Nutrients 2024, 16, 784.
Colletti, A.; Procchio, C.; Pisano, M.; Martelli, A.; Pellizzato, M.; Cravotto, G. An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study. Nutrients2024, 16, 784.
Colletti, A.; Procchio, C.; Pisano, M.; Martelli, A.; Pellizzato, M.; Cravotto, G. An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study. Nutrients 2024, 16, 784.
Abstract
A three-arm, randomized, placebo controlled clinical study has been performed to evaluate the effects of a lyophilized pineapple extract titrated in bromelain (Brome-Inf®), and purified bro-melain on pain, swelling, trismus and quality of life (QoL) after the surgical removal of the lower third molars. Moreover, the need for non-steroidal anti-inflammatory drugs (NSAIDs) has also been evaluated and compared with a placebo group. The study included 42 people that required the extraction of a single mandibular third molar under local anesthesia. The patients were ran-domized and distributed to receive Brome-Inf®, purified bromelain or placebo and started the treatment the day of surgery and continued it for the next 7 days. The primary outcome was the requirement of NSAIDs in the three groups. The outcome variables were pain, swelling and trismus, which were measured postoperatively at 1, 3, and 7 days. The differences in the efficacy of the freeze-dried pineapple extract and single-component bromelain were also evaluated. At the end of the study, the assumption of ibuprofen (from days 1-7) was statistically higher in the placebo group (p
Medicine and Pharmacology, Dentistry and Oral Surgery
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