Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Glycemic Control and Peripheral Arterial Disease in Diabetic Foot Patients

Version 1 : Received: 13 February 2024 / Approved: 13 February 2024 / Online: 13 February 2024 (09:52:04 CET)

How to cite: Aragón-Carreño, M. P.; Aldama-Figueroa, A.; Martínez de Jesús, F. R.; Cvetkovic-Vega, A.; Maguiña, J. L. Glycemic Control and Peripheral Arterial Disease in Diabetic Foot Patients. Preprints 2024, 2024020733. https://doi.org/10.20944/preprints202402.0733.v1 Aragón-Carreño, M. P.; Aldama-Figueroa, A.; Martínez de Jesús, F. R.; Cvetkovic-Vega, A.; Maguiña, J. L. Glycemic Control and Peripheral Arterial Disease in Diabetic Foot Patients. Preprints 2024, 2024020733. https://doi.org/10.20944/preprints202402.0733.v1

Abstract

This analytical cross-sectional study was designed to evaluate the association between glycemic control and peripheral arterial disease in patients with diabetic foot with more than ten years of evolution of diabetes mellitus who attended the diabetic foot outpatient clinic of the Guillermo Almenara National Hospital between June 2015 and February 2017. Glycosylated hemoglobin (HbA1C) and ankle-brachial index (ABI) were used to diagnose glycemic control and peripheral arterial disease, respectively. A generalized Poisson log-linear regression model was used to calculate the crude (cPR) and adjusted (aPR) prevalence ratios, with 95% confidence intervals, and a significance level of p < 0.05. 226 patients were included in the study, finding 23% (n=52) with good glycemic control, and 44.7% (n=101) with peripheral arterial disease. The adjusted model found statistically significant associations for glycemic control, age, and sedentary lifestyle with peripheral arterial disease. Compared with patients with good glycemic control, those with poor glycemic control had a 34% higher probability of presenting peripheral arterial disease (aPR: 1.34, 95%CI: 1.01-1.79, p=0.045). The prevalence of good glycemic control in the population with diabetic foot is low. Poor glycemic control was found to be independently associated with the presence of peripheral arterial disease.

Keywords

Glycemic control; Glycosylated Hemoglobin; Peripherical arterial disease; Diabetic foot; ankle-brachial index.

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

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