Version 1
: Received: 8 February 2024 / Approved: 12 February 2024 / Online: 13 February 2024 (09:18:09 CET)
How to cite:
Temelie-Olinici, D.; Botezatu, I. C.; Perțea, M.; Stoica, L.; Onofrei, P.; Botez, A. E.; Grecu, V. B.; Bărgăoanu, P.; Cotrutz, C. E. Cellular Patterns of the Skin Microenvironment in Experimentally Induced Diabetes Mellitus. Preprints2024, 2024020714. https://doi.org/10.20944/preprints202402.0714.v1
Temelie-Olinici, D.; Botezatu, I. C.; Perțea, M.; Stoica, L.; Onofrei, P.; Botez, A. E.; Grecu, V. B.; Bărgăoanu, P.; Cotrutz, C. E. Cellular Patterns of the Skin Microenvironment in Experimentally Induced Diabetes Mellitus. Preprints 2024, 2024020714. https://doi.org/10.20944/preprints202402.0714.v1
Temelie-Olinici, D.; Botezatu, I. C.; Perțea, M.; Stoica, L.; Onofrei, P.; Botez, A. E.; Grecu, V. B.; Bărgăoanu, P.; Cotrutz, C. E. Cellular Patterns of the Skin Microenvironment in Experimentally Induced Diabetes Mellitus. Preprints2024, 2024020714. https://doi.org/10.20944/preprints202402.0714.v1
APA Style
Temelie-Olinici, D., Botezatu, I. C., Perțea, M., Stoica, L., Onofrei, P., Botez, A. E., Grecu, V. B., Bărgăoanu, P., & Cotrutz, C. E. (2024). Cellular Patterns of the Skin Microenvironment in Experimentally Induced Diabetes Mellitus. Preprints. https://doi.org/10.20944/preprints202402.0714.v1
Chicago/Turabian Style
Temelie-Olinici, D., Petronela Bărgăoanu and Carmen Elena Cotrutz. 2024 "Cellular Patterns of the Skin Microenvironment in Experimentally Induced Diabetes Mellitus" Preprints. https://doi.org/10.20944/preprints202402.0714.v1
Abstract
Diabetes mellitus is one of the most common endocrinopathies, estimated to affect about 5.4% of the world's population around 2025. It is thought that nearly a third of diabetic patients have some type of skin condition. Frequently, the cutaneous effects of this heterogeneous syndrome are ac-curately detected late in the progressive form of the disease. The main objective of the present study was to identify the main cellular characteristics of the cutaneous microenvironment in exper- imentally induced diabetes mellitus. Skin fragments were harvested from adult white Wistar rats of both sexes, with the weight of 200 g, 12 weeks after streptozotocin diabetes was induced. In parallel with histopathological diagnosis by using hematoxylin and eosine staining, samples were processed by transmission electron microscopy technique and examined with a Philips CM100 microscope. In the apparently macroscopically unchanged tegument, photon microscopy revealed both progres ive thinning of the epidermis in the early stages of diabetes and a significant process of fibrosis and collagen hyalinization in the dermis. In addition, in the early stages, the electron microscopic study provided ultrastructural details characteristic of a senescent phenotype with reduced cell proliferation. The morphological changes in the skin may be the first signs of disruption of carbohydrate metabolism and in the case of established diabetes may reflect its progression and the efficacy of therapy.
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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