Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation

Dandan Jia; Huijie Zhang; Tiemin Liu; Ru Wang

doi:10.20944/preprints202402.0431.v1

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preprints.org > biology and life sciences > endocrinology and metabolism > doi: 10.20944/preprints202402.0431.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation

^* ,

Version 1 : Received: 7 February 2024 / Approved: 7 February 2024 / Online: 7 February 2024 (13:11:12 CET)

A peer-reviewed article of this Preprint also exists.

Jia, D.; Zhang, H.; Liu, T.; Wang, R. Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation. Metabolites 2024, 14, 135. Jia, D.; Zhang, H.; Liu, T.; Wang, R. Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation. Metabolites 2024, 14, 135.

Abstract

Adipose tissue undergoes changes with aging, leading to increased adiposity, inflammatory cell infiltration, reduced angiogenesis, heightened oxidative stress, and alterations in its metabolic function. Regular exercise has been recognized as a powerful intervention that can positively influence adipose tissue health and mitigate the effects of aging. However, the molecular mechanisms underlying the benefits of regular exercise on aging adipose tissue function remain poorly understood. Adipokines released through regular exercise play a potential role in mitigating adipose tissue aging, enhancing the metabolism of glucose and lipids, reducing inflammation and fibrosis, and promoting fat browning and thermogenesis. The goal of this review is to offer a comprehensive overview of the benefits of regular exercise in addressing the age-related decline in adipose tissue function. The significance of regular exercise in mitigating metabolic disorders associated with aged adipose tissue will be discussed.

Keywords

exercise; adipose tissue; aging; adipokines

Subject

Biology and Life Sciences, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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