Tao, J.; Li, B.; Shi, Y.; Cheng, J.; Tang, P.; Jiao, J.; Liu, H. Genomic Evolution and Selective Pressure Analysis of a Novel Porcine Sapovirus in Shanghai, China. Microorganisms2024, 12, 569.
Tao, J.; Li, B.; Shi, Y.; Cheng, J.; Tang, P.; Jiao, J.; Liu, H. Genomic Evolution and Selective Pressure Analysis of a Novel Porcine Sapovirus in Shanghai, China. Microorganisms 2024, 12, 569.
Tao, J.; Li, B.; Shi, Y.; Cheng, J.; Tang, P.; Jiao, J.; Liu, H. Genomic Evolution and Selective Pressure Analysis of a Novel Porcine Sapovirus in Shanghai, China. Microorganisms2024, 12, 569.
Tao, J.; Li, B.; Shi, Y.; Cheng, J.; Tang, P.; Jiao, J.; Liu, H. Genomic Evolution and Selective Pressure Analysis of a Novel Porcine Sapovirus in Shanghai, China. Microorganisms 2024, 12, 569.
Abstract
Porcine sapovirus (PoSaV) is a significant pathogen causing diarrhea with high morbidity and mortality rates. Given its zoonotic characteristics, this study conducts a comprehensive genetic evolutionary analysis of PoSaV. Results confirmed PoSaV as the primary RNA virus in piglet feces (27.54%). Phylogenetic analysis identifies the prevalent PoSaV strain SHCM/Mega2023 in the GIII genogroup, involving a recombinant event with MK962338 and KT922089. The time tree revealed that the GIII genogroup exhibits the widest divergence time span, indicating a high likelihood of viral recombination. Further selective pressure calculations demonstrate that PoSaV was under purifying selection (dN/dS < 1), with seven positively selected sites in VP1 protein which might be related to the antigencity. In conclusion, this study presents a novel genomic evolution of PoSaV, offering valuable insights into antigenicity and vaccine research.
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright:
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