Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Dual-Energy CT Iodine Uptake of Head and Neck: Definition of Reference Values in a Big Data Cohort

Ibrahim Yel
* ,
Giuseppe Mauro Bucolo
ORCID logo ,
Scherwin Mahmoudi
,
Vitali Koch
ORCID logo ,
Aynur Gökduman
,
Tommaso D'Angelo
ORCID logo ,
Leon David Grünewald
,
Mirela Dimitrova
ORCID logo ,
Katrin Eichler
,
Thomas J. Vogl
ORCID logo ,
Christian Booz
Version 1 : Received: 4 February 2024 / Approved: 5 February 2024 / Online: 5 February 2024 (10:07:04 CET)

A peer-reviewed article of this Preprint also exists.

Yel, I.; Bucolo, G.M.; Mahmoudi, S.; Koch, V.; Gökduman, A.; D′Angelo, T.; Grünewald, L.D.; Dimitrova, M.; Eichler, K.; Vogl, T.J.; Booz, C. Dual-Energy CT Iodine Uptake of Head and Neck: Definition of Reference Values in a Big Data Cohort. Diagnostics 2024, 14, 496. Yel, I.; Bucolo, G.M.; Mahmoudi, S.; Koch, V.; Gökduman, A.; D′Angelo, T.; Grünewald, L.D.; Dimitrova, M.; Eichler, K.; Vogl, T.J.; Booz, C. Dual-Energy CT Iodine Uptake of Head and Neck: Definition of Reference Values in a Big Data Cohort. Diagnostics 2024, 14, 496.

Abstract

Abstract Purpose Despite a considerable amount of literature on dual-energy-CT(DECT) iodine uptake of the head and neck, the physiologic iodine uptake of this region has not been defined yet. This study aims to establish reference values for the iodine uptake of healthy organs to facilitate clinical application. Material and Methods: Consecutive venous DECT scans of head and neck were reviewed, and unremarkable exams were included (n=617). 35 region of interest measurements were performed in 16 anatomical regions. Iodine uptake was compared among different organs/tissues and subgroup analysis was performed (male [n=403] vs female [n=214]; young [n=207] vs middle-aged [n=206] vs old [n=204]; normal weight [n=314] vs overweight [n=196] vs obese [n=107]]). Results: Overall mean iodine uptake values ranged between 0.5 and 9.4mg/ml. Women showed higher iodine concentration in the cervical vessels and higher uptake for the parotid gland, masseter muscle, submandibular glands, sublingual glands, palatine tonsils, tongue body, thyroid gland, and the sternocleidomastoid muscle than men (p0.04). With increasing age, intravascular iodine concentrations increased as well as iodine uptake for cerebellum and thyroid gland, while values for tongue and palatine tonsils were lower compared to younger subjects (p0.03). Iodine concentrations for parotid glands and sternocleidomastoid muscles decreased with higher BMI (p0.004), while normal-weighted patients showed higher iodine values inside the jugular veins, other cervical glands, and tonsils versus patients with higher BMI (p0.04). Conclusion: Physiologic iodine uptake values of cervical organs and tissues show gender-, age-, and BMI-related differences, which should be considered in clinical routine of head and neck DECT.

Keywords

iodine contrast media; iodine quantification; iodine uptake reference values; computed tomography; head and neck imaging

Subject

Medicine and Pharmacology, Other

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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