Moisii, P.; Jari, I.; Naum, A.G.; Butcovan, D.; Tinica, G. Takayasu’s Arteritis: A Special Case Report and Review of the Literature. Medicina2024, 60, 456.
Moisii, P.; Jari, I.; Naum, A.G.; Butcovan, D.; Tinica, G. Takayasu’s Arteritis: A Special Case Report and Review of the Literature. Medicina 2024, 60, 456.
Moisii, P.; Jari, I.; Naum, A.G.; Butcovan, D.; Tinica, G. Takayasu’s Arteritis: A Special Case Report and Review of the Literature. Medicina2024, 60, 456.
Moisii, P.; Jari, I.; Naum, A.G.; Butcovan, D.; Tinica, G. Takayasu’s Arteritis: A Special Case Report and Review of the Literature. Medicina 2024, 60, 456.
Abstract
Background: Takayasu’s arteritis is a rare type of vasculitis, with severe complications like stroke, ischemic heart disease, pulmonary hypertension, secondary hypertension, aneurysms. Diagnosis is conducted by clinical and angiographic criteria. Treatment is medical and surgical, but unfortunately, the outcome is reserved. Case presentation: A 34- year- old Caucasian women had an ischemic stroke (2009). She was diagnosed with Takayasu’s arteritis and she received treatment with methotrexate, prednisolone, antiplatelet agents, with a mild improvement of clinical state. After 5 years (2014) she associated ascending aorta aneurysm, pulmonary hypertension, mild aortic regurgitation. The surgical treatment solved both ascending aorta aneurysm and left carotid artery stenosis (ultrasound in 2009 and computed tomography angiogram in 2014). Morphopathology revealed typical appearance for Takayasu’s arteritis. Tumor necrosis factor inhibitors (TNF-inhibitors) were associated to methotrexate. At 48 years (2023) she developed coronary heart disease (angina, electrocardiogram); echocardiography revealed severe pulmonary hypertension; angiography described normal coronary arteries, abdominal aorta pseudoaneurysm and arterial-venous fistula, with origin in right coronary artery and drainage on medium pulmonary artery. The patient refused surgical/ interventional treatment; she received again TNF- inhibitors, methotrexate, antiplatelet agents, statins. Conclusions: This case report presents us a severe form of Takayasu’s arteritis. We consider that morphopathology had a great importance in revealing to clinicians the typical appearance and the stadialization of inflammatory arterial process: acute or chronic. The verdict of morphopathologist was chronic phase, with acute relapses, so we decided that immunosuppressive treatment was still necessary.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
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