Version 1
: Received: 30 January 2024 / Approved: 31 January 2024 / Online: 31 January 2024 (12:56:21 CET)
How to cite:
Kaya Terzi, N.; Yulek, O. Assessment of Cervicovaginal Smear and HPV DNA Cotest for Cervical Cancer Screening: Implications for Diagnosis and Follow-Up Strategies. Preprints2024, 2024012187. https://doi.org/10.20944/preprints202401.2187.v1
Kaya Terzi, N.; Yulek, O. Assessment of Cervicovaginal Smear and HPV DNA Cotest for Cervical Cancer Screening: Implications for Diagnosis and Follow-Up Strategies. Preprints 2024, 2024012187. https://doi.org/10.20944/preprints202401.2187.v1
Kaya Terzi, N.; Yulek, O. Assessment of Cervicovaginal Smear and HPV DNA Cotest for Cervical Cancer Screening: Implications for Diagnosis and Follow-Up Strategies. Preprints2024, 2024012187. https://doi.org/10.20944/preprints202401.2187.v1
APA Style
Kaya Terzi, N., & Yulek, O. (2024). Assessment of Cervicovaginal Smear and HPV DNA Cotest for Cervical Cancer Screening: Implications for Diagnosis and Follow-Up Strategies. Preprints. https://doi.org/10.20944/preprints202401.2187.v1
Chicago/Turabian Style
Kaya Terzi, N. and Ozden Yulek. 2024 "Assessment of Cervicovaginal Smear and HPV DNA Cotest for Cervical Cancer Screening: Implications for Diagnosis and Follow-Up Strategies" Preprints. https://doi.org/10.20944/preprints202401.2187.v1
Abstract
OBJECTIVE: Cervical cancer is a major cause of cancer-related mortality, necessitating effective screening and diagnostic methods. This study aimed to assess the performance of cervicovaginal smear (CVS) and Human papilloma virus (HPV)-DNA cotest.
STUDY DESIGN: The pathology results of 225 female patients who underwent HPV-DNA testing with CVS between 2014 and 2022 and were subsequently diagnosed by colposcopic cervical biopsy or second CVS were retrospectively analyzed.
RESULTS: CVS samples showed Atypical Squamous Cells of Undetermined Significance (ASCUS), Low-grade squamous intraepithelial lesion (LSIL), High-grade squamous intraepithelial lesion (HSIL) and cervical cancer. Concordance between the first and second diagnoses demonstrated moderate agreement for LSIL. ASCUS cases exhibited a significant correlation with HPV-DNA positivity and higher-grade cervical lesions. In biopsy, sensitivity and specificity for CIN 2 were 67.8% and 67.9%, respectively, while for CIN 3, they were 81.8% and 58.5%. HPV testing showed significant correlation with histopathologic results. In women over 40 years, more intraepithelial lesions were diagnosed compared to younger women (p<0.005). The conventional smear technique proved reliable in detecting high-grade lesions.
CONCLUSION: Despite the limitations of our study, our results emphasize the value of HPV-DNA testing to avoid unnecessary interventions and to establish appropriate follow-up strategies.
Keywords
cervical cancer screening; colposcopy; conventional smear; liquid-based cytology; HPV
Subject
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
