Nedeljkovic-Arsenovic, O.; Ristić, A.; Đorđević, N.; Tomić, M.; Krljanac, G.; Maksimović, R. Cardiac Magnetic Resonance Imaging as a Risk Stratification Tool in COVID-19 Myocarditis. Diagnostics2024, 14, 790.
Nedeljkovic-Arsenovic, O.; Ristić, A.; Đorđević, N.; Tomić, M.; Krljanac, G.; Maksimović, R. Cardiac Magnetic Resonance Imaging as a Risk Stratification Tool in COVID-19 Myocarditis. Diagnostics 2024, 14, 790.
Nedeljkovic-Arsenovic, O.; Ristić, A.; Đorđević, N.; Tomić, M.; Krljanac, G.; Maksimović, R. Cardiac Magnetic Resonance Imaging as a Risk Stratification Tool in COVID-19 Myocarditis. Diagnostics2024, 14, 790.
Nedeljkovic-Arsenovic, O.; Ristić, A.; Đorđević, N.; Tomić, M.; Krljanac, G.; Maksimović, R. Cardiac Magnetic Resonance Imaging as a Risk Stratification Tool in COVID-19 Myocarditis. Diagnostics 2024, 14, 790.
Abstract
The aim of this retrospective study was to identify myocardial injury after COVID-19 inflamation and to explore whether myocardial damage could be a possible cause of the persistent symptoms following COVID-19 infection in previously healthy individuals.
The study included 139 patients who were enrolled between January-June 2021, mean age 46.7±15.2 years, 68 were men, 71 were women without known cardiac or pulmonary diseases. All patients underwent clinical work up, lab. analyses, cardiac ultrasound, and CMR on 1.5 T scanner using a recommended protocol for morphological and functional assessment before and after contrast media application with multi-parametric sequences.
In 39% of patients late gadolinium enhancement (LGE) was found as a sign of myocarditis. Fibrinogen was statistically significantly higher in patients with LGE than in those without LGE, (4.3±0.23 vs 3.2±0.14g/L, p<0.05; respectively), as well as D-dimer (1.8±0.3 vs 0.8±0.1 mg/L FEU). Also troponin was statistically significantly higher in patients with myocardial LGE (13.1±0.4ng/L) compared to those with normal myocardium (4.9±0.3ng/L, p<0.001). We demonstrated chest pain, fatigue and elevated troponin to be independent predictors for LGE. Septal LGE was shown to be predictor for arrhythmias.
The use of CMR is a potential risk stratification tool in evaluating outcomes following COVID-19 myocarditis.
Keywords
myocarditis; COVID-19 infection; Cardiac magnetic resonance; Late Gadolinium Enhancement and prognosis
Subject
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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