Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Increase of Prominent Probiotics Represents the Major Change in the Gut Microbiota in Female Morbid Obese Patients upon Bariatric Surgery and Are Accompanied with a Switch of Enterotypes

Ann-Kathrin Kissmann
ORCID logo ,
Frederike Paß
,
Hans-Maximilian Ruzicka
,
Isabel Dorst
,
Kai R. Stieger
,
Tanja Weil
,
Adrian Gihring
,
Leonard Elad
,
Uwe Knippschild
ORCID logo ,
Frank Rosenau
* ORCID logo
Version 1 : Received: 29 January 2024 / Approved: 30 January 2024 / Online: 30 January 2024 (05:26:07 CET)

A peer-reviewed article of this Preprint also exists.

Kissmann, A.-K.; Paß, F.; Ruzicka, H.-M.; Dorst, I.; Stieger, K.R.; Weil, T.; Gihring, A.; Elad, L.; Knippschild, U.; Rosenau, F. An Increase in Prominent Probiotics Represents the Major Change in the Gut Microbiota in Morbidly Obese Female Patients upon Bariatric Surgery. Women 2024, 4, 86-104. Kissmann, A.-K.; Paß, F.; Ruzicka, H.-M.; Dorst, I.; Stieger, K.R.; Weil, T.; Gihring, A.; Elad, L.; Knippschild, U.; Rosenau, F. An Increase in Prominent Probiotics Represents the Major Change in the Gut Microbiota in Morbidly Obese Female Patients upon Bariatric Surgery. Women 2024, 4, 86-104.

Abstract

The global increase in obesity has significant health implications, with an increased BMI as a known risk factor for diseases such as type 2 diabetes, cardiovascular diseases, or different cancer types. Long-term effectiveness of diet therapy in addressing morbid obesity is extremely limited with no adequate pharmaceutical agents available as treatment option resulting in bariatric surgery as being the only viable option to achieve and maintain significant long-term weight loss. One important role in the overall human health plays the gut microbiome and its complex composition, which is usually altered and reduced in complexity/diversity in severely obese patients. In this study, the influence of bariatric surgery and the resulting weight-loss on the gut microbiome composition of twelve morbid obese (BMI ≥ 40) female adult central European patients was investigated by comparing the relative abundances of the major microbial phyla Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria prior- and post-surgery. We also aimed to give insight into the major changes of individual prominent and promising future probiotic bacteria characterized by an overall increase in abundance accompanied by a switch of enterotypes. Identifying specific microbial alterations associated with successful weight-loss outcomes may contribute to the development of future therapeutic interventions by supplementation with next-generation probiotics.

Keywords

gut microbiome; 16S rRNA sequencing; obesity; bariatric surgery; enterotypes

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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