Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Wide-Field Choroidal Thickness Analysis after Half-fluence Photodynamic Therapy in Pachychoroid Neovasculopathy

Yosuke Fukuda
,
Shoji Notomi
* ORCID logo ,
Satomi Shiose
,
Yusuke Maehara
,
Kohei Kiyohara
,
Sawako Hashimoto
,
Kumiko Kano
,
Keijiro Ishikawa
,
Toshio Hisatomi
,
Koh-Hei Sonoda
Version 1 : Received: 27 January 2024 / Approved: 29 January 2024 / Online: 29 January 2024 (13:01:33 CET)

A peer-reviewed article of this Preprint also exists.

Fukuda, Y.; Notomi, S.; Shiose, S.; Maehara, Y.; Kiyohara, K.; Hashimoto, S.; Kano, K.; Ishikawa, K.; Hisatomi, T.; Sonoda, K.-H. Wide-Field Choroidal Thickness Analysis after Half-Fluence Photodynamic Therapy Combined with Intravitreal Aflibercept Injection in Pachychoroid Neovasculopathy. J. Clin. Med. 2024, 13, 1608. Fukuda, Y.; Notomi, S.; Shiose, S.; Maehara, Y.; Kiyohara, K.; Hashimoto, S.; Kano, K.; Ishikawa, K.; Hisatomi, T.; Sonoda, K.-H. Wide-Field Choroidal Thickness Analysis after Half-Fluence Photodynamic Therapy Combined with Intravitreal Aflibercept Injection in Pachychoroid Neovasculopathy. J. Clin. Med. 2024, 13, 1608.

Abstract

Pachychoroid neovasculopathy (PNV) is a pachychoroid-spectrum disease. As blood circulation throughout the choroid may be involved in PNV pathogenesis, analysis using ultra-wide-field (UWF) fundus imaging is crucial. We evaluated choroidal thickness after half-fluence photodynamic therapy (PDT) combined with intravitreal aflibercept injection for PNV using UWF swept-source optical coherence tomography. Seventeen eyes with PNV that underwent half-fluence PDT with adjuvant single intravitreal aflibercept injection were analyzed. To compare choroidal thicknesses in the central and peripheral choroids, we set subfields <3, <9, and 9–18 mm from the fovea. The <9- and 9–18-mm subfields were divided into four quadrants. Choroidal thickness in each subfield decreased significantly after half-fluence PDT (P<0.001); this reduction was more pronounced in the central area. We also investigated the relationship between the dominant side of the deep choroidal veins that harbor choroidal vein efflux from the macula. When choroidal thickness in the supratemporal and infratemporal 9x9-mm subfields were evaluated, the ratio of choroidal thickness reduction was not significantly different between the dominant and non-dominant sides. The dominant side was not associated with the extent of choroidal thickness reduction in PNV. In conclusion, half-fluence PDT caused thinning of the entire choroid, especially in the central area, in PNV.

Keywords

age-related macular degeneration; pachychoroid neovasculopathy; photodynamic therapy; anti-vascular endothelial growth factor therapy; ultra-wide-field optical coherent tomography

Subject

Medicine and Pharmacology, Ophthalmology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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