Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Effects of PM10 Airborne Particles from Different Regions and Seasons of a Megacity on In-Vitro Secretion of Cytokines by a Monocyte Line.

Noemi Meraz - Cruz
ORCID logo ,
Natalia Manzano-León
,
Daniel Eduardo Sandoval-Colin
ORCID logo ,
Maria del Carmen García de León-Mendez
,
Raúl Quintana
ORCID logo ,
Laura Sevilla
,
Alvaro R. Osornio
ORCID logo ,
Miatta A. Buxton
ORCID logo ,
Marie S. O´Neill
ORCID logo ,
Felipe Vadillo-Ortega
* ORCID logo
Version 1 : Received: 26 January 2024 / Approved: 26 January 2024 / Online: 26 January 2024 (17:40:12 CET)

A peer-reviewed article of this Preprint also exists.

Meraz-Cruz, N.; Manzano-León, N.; Sandoval-Colin, D.E.; García de León Méndez, M.C.; Quintana-Belmares, R.; Tapia, L.S.; Osornio-Vargas, A.R.; Buxton, M.A.; O’Neill, M.S.; Vadillo-Ortega, F. Effects of PM10 Airborne Particles from Different Regions of a Megacity on In Vitro Secretion of Cytokines by a Monocyte Line during Different Seasons. Toxics 2024, 12, 149. Meraz-Cruz, N.; Manzano-León, N.; Sandoval-Colin, D.E.; García de León Méndez, M.C.; Quintana-Belmares, R.; Tapia, L.S.; Osornio-Vargas, A.R.; Buxton, M.A.; O’Neill, M.S.; Vadillo-Ortega, F. Effects of PM10 Airborne Particles from Different Regions of a Megacity on In Vitro Secretion of Cytokines by a Monocyte Line during Different Seasons. Toxics 2024, 12, 149.

Abstract

Several epidemiological studies have demonstrated that particulate matter (PM) in air pollution can be involved in the genesis or aggravation of different cardiovascular, respiratory, perinatal, and cancer diseases. This study assessed the in vitro effects of PM <10 μm in aerodynamic diameter (PM10) on the secretion of cytokines by a human monocytic cell line (THP-1). We compared the chemotactic, pro-inflammatory, and anti-inflammatory cytokines induced by PM10 collected for two years during three different seasons in five different Mexico City locations. MIP-1α, IP-10, MCP-1, TNF-α, and VEGF were the main secretion products after stimulation with 80 μg/mL of PM10 for 24 hours. The THP-1 cells showed a differential response to PM10 obtained in the different sites of Mexico City. The PM10 from the north and the central city areas induced a higher pro-inflammatory cytokine response than those from the south. Seasonal pro-inflammatory cytokine secretion always exceeded the anti-inflammatory one. The rainy season-derived particles caused the lowest pro-inflammatory effects. We concluded that toxicological assessment of airborne particles provides evidence supporting their potential role in chronic exacerbation of local or systemic inflammatory responses that may worsen the evolution of some chronic diseases.

Keywords

PM10; cytokine; pollution

Subject

Biology and Life Sciences, Toxicology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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