Version 1
: Received: 22 January 2024 / Approved: 22 January 2024 / Online: 22 January 2024 (10:49:10 CET)
How to cite:
Zhu, J.; Jiang, L.; Zhang, J.; Wen, J. Overview of Experimental Findings of Animal Models for Primary Flavivirus Infection. Preprints2024, 2024011587. https://doi.org/10.20944/preprints202401.1587.v1
Zhu, J.; Jiang, L.; Zhang, J.; Wen, J. Overview of Experimental Findings of Animal Models for Primary Flavivirus Infection. Preprints 2024, 2024011587. https://doi.org/10.20944/preprints202401.1587.v1
Zhu, J.; Jiang, L.; Zhang, J.; Wen, J. Overview of Experimental Findings of Animal Models for Primary Flavivirus Infection. Preprints2024, 2024011587. https://doi.org/10.20944/preprints202401.1587.v1
APA Style
Zhu, J., Jiang, L., Zhang, J., & Wen, J. (2024). Overview of Experimental Findings of Animal Models for Primary Flavivirus Infection. Preprints. https://doi.org/10.20944/preprints202401.1587.v1
Chicago/Turabian Style
Zhu, J., Jiayi Zhang and Jinsheng Wen. 2024 "Overview of Experimental Findings of Animal Models for Primary Flavivirus Infection" Preprints. https://doi.org/10.20944/preprints202401.1587.v1
Abstract
The genus Flavivirus includes 53 members and poses a big threat to human health among worldwide. Diseases caused by flavivirus infections can be broadly classified into hemorrhagic diseases (Dengue, Yellow fever, etc) and neurological diseases (West Nile disease, Zika disease, etc). Many flaviviruses still lack specific treatments and effective vaccines. In this context, it becomes particularly important to thoroughly characterize the pathogenesis of flavivirus infection and develop animal models. Therefore, animal models that can accurately simulate human diseases are essential for evaluating the effectiveness of therapeutic drugs and preventive vaccines. In this paper, we provide a comprehensive review of the currently available animal models that support flavivirus infection and exhibit clinical manifestations related to flavivirus infection. Additionally, we discuss the strengths and limitations of each animal model, aiming to enhance researchers understanding of the use of animal models in flavivirus research. This insight is intended to facilitate further studies into the pathogenesis of flavivirus, as well as the development of antiviral agents and vaccines.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
