Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Normal Triglycerides Are Positively Associated with Plasma Glucose and Risk for Type 2 Diabetes in Chinese Adults

Yutang Wang
* ORCID logo ,
Hongying Liu
,
Shenzhou Ma
,
Tingting Qian
,
Hui Sun
,
Qun Xu
,
Xujuan Hou
,
Wenqi Hu
,
Guang Zhang
,
Maria Jelinic
,
Andreas JR Habenicht
ORCID logo ,
David Song
,
Guang Yang
*
Version 1 : Received: 18 January 2024 / Approved: 19 January 2024 / Online: 19 January 2024 (12:47:07 CET)

How to cite: Wang, Y.; Liu, H.; Ma, S.; Qian, T.; Sun, H.; Xu, Q.; Hou, X.; Hu, W.; Zhang, G.; Jelinic, M.; Habenicht, A.J.; Song, D.; Yang, G. Normal Triglycerides Are Positively Associated with Plasma Glucose and Risk for Type 2 Diabetes in Chinese Adults. Preprints 2024, 2024011501. https://doi.org/10.20944/preprints202401.1501.v1 Wang, Y.; Liu, H.; Ma, S.; Qian, T.; Sun, H.; Xu, Q.; Hou, X.; Hu, W.; Zhang, G.; Jelinic, M.; Habenicht, A.J.; Song, D.; Yang, G. Normal Triglycerides Are Positively Associated with Plasma Glucose and Risk for Type 2 Diabetes in Chinese Adults. Preprints 2024, 2024011501. https://doi.org/10.20944/preprints202401.1501.v1

Abstract

This study aimed to examine the association of blood triglyceride levels with fasting blood glucose levels and type 2 diabetes (T2D) prevalence in Chinese adults with normal triglyceride levels (<1.7 mmol/L), using linear regression and binary logistic regression, respectively. This cross-sectional study included 16,706 Chinese adults, among which 1,067 had T2D. Triglycerides were positively associated with fasting plasma glucose after multivariate adjustment (β=0.034, P<0.001). One natural log unit increase in blood triglycerides was associated with a 61% higher multivari-ate-adjusted risk of T2D (odds ratio [OR], 1.61; 95% confidence interval [CI], 1.19-2.17; P=0.002). The positive associations remained when participants who were treated with lipid-lowering or an-ti-diabetic drugs were excluded. The optimal cut-off of triglycerides for T2D was 1.09 mmol/L (obtained using Receiver Operating Characteristic curve analysis). Participants with triglycerides of ≥1.09 mmol/L had a 28% higher risk of T2D (OR, 1.28; 95% CI, 1.07-1.53; P=0.006) compared to those with triglycerides below the cut-off. In conclusion, this study showed that, in people with normal triglyceride levels, triglycerides at the upper normal range correlated with increased T2D diagnosis risk, with an optimal cut-off of 1.09 mmol/L. Therefore, adults with high “normal” triglyceride levels (1.09-1.69 mmol/L) may need to be closely monitored for the development of T2D.

Keywords

diabetes mellitus; triglyceride; glucose; association; risk factor

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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