Antibacterial, Anti-biofilm and Anti-inflammatory Properties of G-CH-M Biopolymer-Based Wound Dressings towards Staphylococcus aureus and Escherichia coli

Asim Faraz; Salma Bessalah; Mohamed Dbara; Touhami Khorcheni; Mohamed Hammadi; Syeda Maryam Hussain; Muhammad Furqan Ilyas; Daniel Jesuwenu Ajose; Chanda Liaqat; Shamsaldeen I. Saeed

doi:10.20944/preprints202401.1442.v1

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preprints.org > medicine and pharmacology > complementary and alternative medicine > doi: 10.20944/preprints202401.1442.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Antibacterial, Anti-biofilm and Anti-inflammatory Properties of G-CH-M Biopolymer-Based Wound Dressings towards Staphylococcus aureus and Escherichia coli

Muhammad Furqan Ilyas

Daniel Jesuwenu Ajose

Chanda Liaqat

Shamsaldeen I. Saeed

Version 1 : Received: 17 January 2024 / Approved: 19 January 2024 / Online: 19 January 2024 (09:24:10 CET)

How to cite: Faraz, A.; Bessalah, S.; Dbara, M.; Khorcheni, T.; Hammadi, M.; Hussain, S.M.; Ilyas, M.F.; Ajose, D.J.; Liaqat, C.; Saeed, S.I. Antibacterial, Anti-biofilm and Anti-inflammatory Properties of G-CH-M Biopolymer-Based Wound Dressings towards Staphylococcus aureus and Escherichia coli. Preprints 2024, 2024011442. https://doi.org/10.20944/preprints202401.1442.v1 Faraz, A.; Bessalah, S.; Dbara, M.; Khorcheni, T.; Hammadi, M.; Hussain, S.M.; Ilyas, M.F.; Ajose, D.J.; Liaqat, C.; Saeed, S.I. Antibacterial, Anti-biofilm and Anti-inflammatory Properties of G-CH-M Biopolymer-Based Wound Dressings towards Staphylococcus aureus and Escherichia coli. Preprints 2024, 2024011442. https://doi.org/10.20944/preprints202401.1442.v1

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MDPI and ACS Style

Faraz, A.; Bessalah, S.; Dbara, M.; Khorcheni, T.; Hammadi, M.; Hussain, S.M.; Ilyas, M.F.; Ajose, D.J.; Liaqat, C.; Saeed, S.I. Antibacterial, Anti-biofilm and Anti-inflammatory Properties of G-CH-M Biopolymer-Based Wound Dressings towards Staphylococcus aureus and Escherichia coli. Preprints 2024, 2024011442. https://doi.org/10.20944/preprints202401.1442.v1

APA Style

Faraz, A., Bessalah, S., Dbara, M., Khorcheni, T., Hammadi, M., Hussain, S.M., Ilyas, M.F., Ajose, D.J., Liaqat, C., & Saeed, S.I. (2024). Antibacterial, Anti-biofilm and Anti-inflammatory Properties of G-CH-M Biopolymer-Based Wound Dressings towards Staphylococcus aureus and Escherichia coli. Preprints. https://doi.org/10.20944/preprints202401.1442.v1

Chicago/Turabian Style

Faraz, A., Chanda Liaqat and Shamsaldeen I. Saeed. 2024 "Antibacterial, Anti-biofilm and Anti-inflammatory Properties of G-CH-M Biopolymer-Based Wound Dressings towards Staphylococcus aureus and Escherichia coli" Preprints. https://doi.org/10.20944/preprints202401.1442.v1

Abstract

Biological polymers such as tissue-engineered scaffolds and skin grafts with improved properties are very required in the pharmaceutical field. The wound-dressing gelatin/chitosan/moringa leaf extract (G-CH-M biopolymer) was synthesised and characterised. The blood compatibility, anti-inflammatory, antioxidant, and antibacterial activities of the biopolymer were investigated. Our results showed that S. aureus swarming motility was drastically affected. However, the biopolymer had no significant effect on the swarming motility of E. coli compared to the control. In addition, biopolymers showed high antibacterial capacities, especially against S. aureus. The biopolymer was also found to be effective in protecting plasmid DNA against oxidative stress. Furthermore, the biopolymer exhibits greatly suppressed hemolysis (lower than 2%), even at a high concentration of 50 mg/mL. These results indicated that this novel biopolymer formulation could be further developed for wound care and contamination prevention.

Keywords

alternative therapy; biomedical; botanical; natural product; pathogen

Subject

Medicine and Pharmacology, Complementary and Alternative Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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