PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Body Composition and Metabolic Consequences of Most Frequent Antibiotics Given to Newborns in Intensive Care Units, an Experimental Study in Newborn Rats
Version 1
: Received: 16 January 2024 / Approved: 16 January 2024 / Online: 16 January 2024 (09:42:12 CET)
How to cite:
Segura-Cervantes, E.; Mancilla-Ramírez, J.; Fernández-Urrutia, L.; González-Gallardo, S.; Mendoza-Gertrudis, L.; Valencia-Santaella, J.; Galindo-Sevilla, N. Body Composition and Metabolic Consequences of Most Frequent Antibiotics Given to Newborns in Intensive Care Units, an Experimental Study in Newborn Rats. Preprints2024, 2024011218. https://doi.org/10.20944/preprints202401.1218.v1
Segura-Cervantes, E.; Mancilla-Ramírez, J.; Fernández-Urrutia, L.; González-Gallardo, S.; Mendoza-Gertrudis, L.; Valencia-Santaella, J.; Galindo-Sevilla, N. Body Composition and Metabolic Consequences of Most Frequent Antibiotics Given to Newborns in Intensive Care Units, an Experimental Study in Newborn Rats. Preprints 2024, 2024011218. https://doi.org/10.20944/preprints202401.1218.v1
Segura-Cervantes, E.; Mancilla-Ramírez, J.; Fernández-Urrutia, L.; González-Gallardo, S.; Mendoza-Gertrudis, L.; Valencia-Santaella, J.; Galindo-Sevilla, N. Body Composition and Metabolic Consequences of Most Frequent Antibiotics Given to Newborns in Intensive Care Units, an Experimental Study in Newborn Rats. Preprints2024, 2024011218. https://doi.org/10.20944/preprints202401.1218.v1
APA Style
Segura-Cervantes, E., Mancilla-Ramírez, J., Fernández-Urrutia, L., González-Gallardo, S., Mendoza-Gertrudis, L., Valencia-Santaella, J., & Galindo-Sevilla, N. (2024). Body Composition and Metabolic Consequences of Most Frequent Antibiotics Given to Newborns in Intensive Care Units, an Experimental Study in Newborn Rats. Preprints. https://doi.org/10.20944/preprints202401.1218.v1
Chicago/Turabian Style
Segura-Cervantes, E., Jasibe Valencia-Santaella and Norma Galindo-Sevilla. 2024 "Body Composition and Metabolic Consequences of Most Frequent Antibiotics Given to Newborns in Intensive Care Units, an Experimental Study in Newborn Rats" Preprints. https://doi.org/10.20944/preprints202401.1218.v1
Abstract
Introduction: Overuse of antibiotics has been increasing in recent years and is currently the most prescribed drug in the paediatric age. It is estimated that 72% of patients in the neonatal intensive care unit (NICU) are treated with antibiotics. One of the effects observed with their use is the alteration of the microbiota, which is associated with metabolic disorders including obesity. In this study, the aim was to determine in newborn rats, whether most commonly prescribed antibiotics in Mexican NICUs have a differential effect on weight gain, development of adiposity, and modification of carbohydrate and lipid metabolism. Methods: This is an experimental study in newborn rats, comparing Ampicillin/Meropenem (Access/Watch groups) 100 mg/g every 12 h /10 mg/g every 12 h (each of these two antibiotics was adjusted to the required dosages based on weight); Cefotaxime 200 mg/g every 24 h; (Watch group) and Amikacin 15 mg/g every 24 h (Access group) versus Saline Solution as Control. Each antibiotic was intraperitoneal administered daily for 5 days in males (to avoid gender differences) to 14 newborn rats in each group. A comparison of anthropometric and biochemical parameters registered on day 28was made using ANOVA analysis. Differences were considered if p < 0.05.Results: Amikacin was the antibiotic with the greatest effect on anthropometric measurements and LDL-cholesterol; as well as Cefotaxime on Glucose and triglycerides, while Meropenem plus Ampicillin showed the weakest effect on measured parameters. Conclusion: The administration of antibiotics in the neonatal stage has repercussions on the body composition of adult rats, as well as on lipids and carbohydrates serum levels. Future studies might evaluate the toxicity of antibiotics on the immature neonatal organs.
Keywords
Antibiotic; Body composition; Newborn; Animal Model; Neonate Development
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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