Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Risk of Severe COVID-19-Related Outcomes among Patients with Cirrhosis: A Population-Based Cohort Study in Canada

Héctor Alexander Velásquez García
ORCID logo ,
Prince A. Adu
* ORCID logo ,
Ada Okonkwo-Dappa
ORCID logo ,
Jean Damascene Makuza
ORCID logo ,
Georgine Cua
,
Mawuena Binka
,
James Wilton
,
Hind Sbihi
,
Naveed Z. Janjua
* ORCID logo
Version 1 : Received: 10 January 2024 / Approved: 11 January 2024 / Online: 11 January 2024 (09:54:24 CET)

A peer-reviewed article of this Preprint also exists.

Velásquez García, H.A.; Adu, P.A.; Okonkwo-Dappa, A.; Makuza, J.D.; Cua, G.; Binka, M.; Wilton, J.; Sbihi, H.; Janjua, N.Z. Risk of Severe COVID-19-Related Outcomes among Patients with Cirrhosis: A Population-Based Cohort Study in Canada. Viruses 2024, 16, 351. Velásquez García, H.A.; Adu, P.A.; Okonkwo-Dappa, A.; Makuza, J.D.; Cua, G.; Binka, M.; Wilton, J.; Sbihi, H.; Janjua, N.Z. Risk of Severe COVID-19-Related Outcomes among Patients with Cirrhosis: A Population-Based Cohort Study in Canada. Viruses 2024, 16, 351.

Abstract

We assessed the association between cirrhosis and severe COVID-19-related outcomes among people with laboratory-diagnosed COVID-19 infection in British Columbia, Canada. We used data from the British Columbia (BC) COVID-19 Cohort, a population-based cohort that integrates data on all individuals tested for COVID-19 with data on hospitalizations, medical visits, emergency room visits, prescription drugs, chronic conditions, and deaths in the Canadian province of BC. We included all individuals, aged ≥ 18 who tested positive for SARS-CoV-2 by real-time reverse transcription-polymerase chain reaction, from January 01, 2021, to December 31, 2021. Multivariable logistic regression models were used to assess the associations between cirrhosis status and COVID-19-related hospitalization and ICU admission. Of the 162,509 individuals who tested positive for SARS-CoV-2 and were included in the analysis, 768 (0.5%) had cirrhosis. In the multivariable models, cirrhosis was associated with increased odds of hospitalization (aOR=1.97, 95% CI: 1.58 – 2.47) and ICU admission (aOR=3.33, 95% CI: 2.56 – 4.35). In the analyses stratified by age, we found that the increased odds of ICU admission among people with cirrhosis were present in all the assessed age-groups. Cirrhosis is associated with increased odds of hospitalization and ICU admission among COVID-19 patients.

Keywords

COVID-19; cirrhosis; risk; hospitalization; risk factors; Canada

Subject

Public Health and Healthcare, Public Health and Health Services

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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