Review
Version 1
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Recent Advances on Therapy of Slowing Progression of Dia-betic Kidney Disease
Version 1
: Received: 4 January 2024 / Approved: 5 January 2024 / Online: 5 January 2024 (10:38:07 CET)
A peer-reviewed article of this Preprint also exists.
Wang, N.; Zhang, C. Recent Advances in the Management of Diabetic Kidney Disease: Slowing Progression. Int. J. Mol. Sci. 2024, 25, 3086. Wang, N.; Zhang, C. Recent Advances in the Management of Diabetic Kidney Disease: Slowing Progression. Int. J. Mol. Sci. 2024, 25, 3086.
Abstract
Diabetic kidney disease (DKD) is the major cause of chronic kidney disease (CKD) and increases the risk of cardiovascular events. Hemodynamic, inflammatory and metabolic factors, which share the convergent pathway of fibrosis, are considered to involve in the pathogenesis of DKD. In spite of the emerging of angiotensin receptors blockers (ARBs)/ angiotensin converting enzyme inhibitor (ACEI), sodium-glucose cotransporter 2 (SGLT2) inhibitors, and nonsteroidal mineralocorticoid receptors antagonists (NS-MRAs), current therapies still couldn’t arrest the progression of DKD. Glucagon like peptide 1 receptor agonists (GLP-1RAs) are promising agents to play renoprotective roles in slowing the progression of DKD. Based on the treatment of heart failure, combined use of drugs is recommended for DKD rather than single use. Unearthing the mechanisms underlying DKD is urgent to investigate the management of DKD. Here, we elaborate on the potential mechanisms and the current therapies of DKD. We also discuss the additional value of the combined use of these drugs for DKD to establish novel concepts of treatment.
Keywords
DKD; molecular mechanisms; ACEI/ARB; SGLT2i; NS-MRAs; GLP-1RAs
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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