Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Early Extra-Uterine Growth Restriction in Very Low Birth Weight Neonates with Normal or Mildly Abnormal Brain MRI: Effects on 2–3 Years Neurodevelopmental Outcome

Paolo Massirio
* ORCID logo ,
Marcella Battaglini
,
Irene Bonato
,
Sara De Crescenzo
,
Maria Grazia Calevo
,
Mariya Malova
,
Samuele Caruggi
,
Alessandro Parodi
* ,
Deborah Preiti
ORCID logo ,
Agata Zoia
,
Sara Uccella
,
Domenico Tortora
ORCID logo ,
Mariasavina Severino
ORCID logo ,
Andrea Rossi
,
Cristina Traggiai
,
Lino Nobili
ORCID logo ,
Pasquale Striano
,
Luca Antonio Ramenghi
*
Version 1 : Received: 1 January 2024 / Approved: 4 January 2024 / Online: 4 January 2024 (09:01:43 CET)

A peer-reviewed article of this Preprint also exists.

Massirio, P.; Battaglini, M.; Bonato, I.; De Crescenzo, S.; Calevo, M.G.; Malova, M.; Caruggi, S.; Parodi, A.; Preiti, D.; Zoia, A.; Uccella, S.; Tortora, D.; Severino, M.; Rossi, A.; Traggiai, C.; Nobili, L.; Striano, P.; Ramenghi, L.A. Early Extra-Uterine Growth Restriction in Very-Low-Birth-Weight Neonates with Normal or Mildly Abnormal Brain MRI: Effects on a 2–3-Year Neurodevelopmental Outcome. Nutrients 2024, 16, 449. Massirio, P.; Battaglini, M.; Bonato, I.; De Crescenzo, S.; Calevo, M.G.; Malova, M.; Caruggi, S.; Parodi, A.; Preiti, D.; Zoia, A.; Uccella, S.; Tortora, D.; Severino, M.; Rossi, A.; Traggiai, C.; Nobili, L.; Striano, P.; Ramenghi, L.A. Early Extra-Uterine Growth Restriction in Very-Low-Birth-Weight Neonates with Normal or Mildly Abnormal Brain MRI: Effects on a 2–3-Year Neurodevelopmental Outcome. Nutrients 2024, 16, 449.

Abstract

Extrauterine growth restriction (EUGR) is a common complication and a known risk factor for impaired development in very low birth weight (VLBW) preterms. We report a population of 288 patients with no or with low grade MRI lesions scanned at term equivalent age (TEA) born between 2012 and 2018. Griffiths mental development scale II (GMDS II) at 2 and 3 years, preterm complications and weight growth were retrospectively analysed. EUGR was defined for weigth z-score ˂10th percentile at TEA, 6 and 12 months of correct age or as z-score decreased by 1-point SDS from birth to TEA and from TEA to 6 months. Multivariate analysis showed that a higher weight z-score at 6 months is protective for global developmental quotient (DQ) at 2 years (OR 0.74; CI 95% 0.59-0.93; p=0,01). EUGR at 6 months was associated with worse locomotor, personal-social, language and performance DQ at 2 years and worse language and practical reasoning DQ at 3 years. In conclusion a worse weight z-score at 6 months of age seems to be an independent risk factor for significantly reduced GMDS in many areas. These results suggest to better invest on post-discharge nutritional, optimizing family nutritional education.

Keywords

preterm; extra-uterine growth restriction; EUGR; VLBW; neurodevelopment; weaning; nutritional education

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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