Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Fibrosis Progression in Patients with Budd-Chiari Syndrome and Transjugular Shunt (TIPS): A Long-Term Study Using Transient Elastography

Version 1 : Received: 2 January 2024 / Approved: 3 January 2024 / Online: 3 January 2024 (10:36:13 CET)

A peer-reviewed article of this Preprint also exists.

Rössle, M.; Bettinger, D.; Sturm, L.; Reincke, M.; Thimme, R.; Schultheiss, M. Fibrosis Progression in Patients with Budd–Chiari Syndrome and Transjugular Intrahepatic Portosystemic Shunt (TIPS): A Long-Term Study Using Transient Elastography. Diagnostics 2024, 14, 344. Rössle, M.; Bettinger, D.; Sturm, L.; Reincke, M.; Thimme, R.; Schultheiss, M. Fibrosis Progression in Patients with Budd–Chiari Syndrome and Transjugular Intrahepatic Portosystemic Shunt (TIPS): A Long-Term Study Using Transient Elastography. Diagnostics 2024, 14, 344.

Abstract

Hepatic vein outflow obstruction causes congestion of the liver, leading to necrosis, fibrosis, and portal hypertension (PH). Transjugular intrahepatic portosystemic shunt (TIPS) reduces congestion and PH by providing artificial outflow. The aim of the study was to investigate fibrosis progression in patients with Budd-Chiari syndrome (BCS) and TIPS using transient elastography (TE). From 2010 to 2022, 25 patients received 80 TEs using FibroScan® (3.2±2.1 per patient). TIPS function was assessed using Doppler ultrasound or radiological intervention. At the time of TE examination, 21 patients had patent shunts. Four patients had occluded shunts but normal pressure gradients during the intervention. The first TE measurement performed 9.8±6.8 years after the BCS diagnosis showed stiffness values of 24.6±11.5 kPa. A second or last measurement performed 7.0±2.9 years after the first measurement showed similar stiffness values of 24.1±15.7 kPa (p=0.943). Except for three patients, the liver stiffness was always >12 kPa, indicating advanced fibrosis. Stiffness values obtained <5 years (n=8, 23,8±9,2 kPa) or >5 years after the BCS diagnosis (24,9±12,7 kPa) did not differ (p=0.907). In addition, stiffness was not related to the interval between BCS and TIPS implantation (p=0.999). One patient received liver transplantation, and two patients died from non-hepatic causes. Most patients develop mild to moderate cirrhosis, possibly during the early phase of the disease. Timing of TIPS did not influence fibrosis progression. This and the release of portal hypertension may argue in favor of a generous TIPS implantation practice in patients with BCS.

Keywords

Budd-Chiari syndrome; Cirrhosis; Fibrosis; transient elastography; Fibroscan

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

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