Gupta, S.; Papidze, T.; Cesmat, A.; Chaudry, A.; Weickert, T.; Simpson Jr., R.; Syed, F.F. Neutrophil-to-Lymphocyte Ratio and Ventricular Arrhythmia in Mitral Valve Prolapse. Preprints2024, 2024010051. https://doi.org/10.20944/preprints202401.0051.v1
APA Style
Gupta, S., Papidze, T., Cesmat, A., Chaudry, A., Weickert, T., Simpson Jr., R., & Syed, F.F. (2024). Neutrophil-to-Lymphocyte Ratio and Ventricular Arrhythmia in Mitral Valve Prolapse. Preprints. https://doi.org/10.20944/preprints202401.0051.v1
Chicago/Turabian Style
Gupta, S., Ross Simpson Jr. and Faisal Fiazuddin Syed. 2024 "Neutrophil-to-Lymphocyte Ratio and Ventricular Arrhythmia in Mitral Valve Prolapse" Preprints. https://doi.org/10.20944/preprints202401.0051.v1
Abstract
: Inflammation may mediate the association of mitral valve prolapse (MVP) with ventricular scarring and arrhythmia. The purpose of this study is to investigate the association of neutrophil- and platelet-to-lymphocyte ratios (NLR, PLR) with ventricular arrhythmia in MVP. Clinical and demographic data were extracted from electronic medical records for all patients aged 18-90 years with MVP on echocardiography between 2016-19 at our institution. We studied 65 patients who had a differential blood count within six months prior to ambulatory ECG (A- ECG) (medi-an age [IQR] 70 [61-77] years; 62% female; 12% African American). Patients with surgery or in-fection within six months prior to CBC were excluded. Complex or frequent ventricular ectopy (cfVE) was defined as the presence of two or more premature ventricular contractions (PVCs) on a 10-second ECG tracing or greater than 1% PVC burden or NSVT on ambulatory ECG monitoring. Logistic and bivariate regression was used to analyze clinical, electrocardiographic and echo-cardiographic factors associated with NLR and PLR. Factors associated with higher NLR were congestive heart failure (p=0.005), male sex (p=0.01), age (p=0.003), and bileaflet MVP (p=0.04). NLR was associated with higher absolute PVC burden (rs=0.28, p=0.03) and cfVE (median NLR [IQR] 3.0 [1.6 – 6.3]) with cfVE versus (2.4 [1.4-3.4], p=0.04) without cfVE. An NLR of 5.6 yielded 50% sensitivity and 90% specificity for PVC burden >1% (AUC 0.69). No significant association was found between PLR and PVC burden or cfVE. NLR is associated with PVC burden and com-plex ventricular ectopy in MVP, suggesting that inflammation is a significant factor in the patho-genesis of ventricular arrhythmia in this condition.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
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