Ethylene-Di-Amine Modified β-Cyclodextrin Catalyzed Green Synthesis of Pyrimidones and Its In Silico Study against ESBL E. coli Receptor

Manojkumar Rajapriyan; Mohammed M. Alanazi; R Imran Khan; Ajmal R. Bhat; Syed Ali Padusha M; Sarkar M. A. Kawsar; Javed Masood Khan; Ayyiliath M Sajith

doi:10.20944/preprints202312.2306.v2

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preprints.org > medicine and pharmacology > medicine and pharmacology > doi: 10.20944/preprints202312.2306.v2

Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

Ethylene-Di-Amine Modified β-Cyclodextrin Catalyzed Green Synthesis of Pyrimidones and Its In Silico Study against ESBL E. coli Receptor

Manojkumar Rajapriyan

^* ,

Version 1 : Received: 28 December 2023 / Approved: 29 December 2023 / Online: 29 December 2023 (14:34:42 CET)
Version 2 : Received: 31 March 2024 / Approved: 1 April 2024 / Online: 2 April 2024 (10:58:54 CEST)

How to cite: Rajapriyan, M.; Alanazi, M.M.; Khan, R.I.; Bhat, A.R.; M, S.A.P.; Kawsar, S.M.A.; Khan, J.M.; Sajith, A.M. Ethylene-Di-Amine Modified β-Cyclodextrin Catalyzed Green Synthesis of Pyrimidones and Its In Silico Study against ESBL E. coli Receptor. Preprints 2023, 2023122306. https://doi.org/10.20944/preprints202312.2306.v2 Rajapriyan, M.; Alanazi, M.M.; Khan, R.I.; Bhat, A.R.; M, S.A.P.; Kawsar, S.M.A.; Khan, J.M.; Sajith, A.M. Ethylene-Di-Amine Modified β-Cyclodextrin Catalyzed Green Synthesis of Pyrimidones and Its In Silico Study against ESBL E. coli Receptor. Preprints 2023, 2023122306. https://doi.org/10.20944/preprints202312.2306.v2

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MDPI and ACS Style

Rajapriyan, M.; Alanazi, M.M.; Khan, R.I.; Bhat, A.R.; M, S.A.P.; Kawsar, S.M.A.; Khan, J.M.; Sajith, A.M. Ethylene-Di-Amine Modified β-Cyclodextrin Catalyzed Green Synthesis of Pyrimidones and Its In Silico Study against ESBL E. coli Receptor. Preprints 2023, 2023122306. https://doi.org/10.20944/preprints202312.2306.v2

APA Style

Rajapriyan, M., Alanazi, M.M., Khan, R.I., Bhat, A.R., M, S.A.P., Kawsar, S.M.A., Khan, J.M., & Sajith, A.M. (2024). Ethylene-Di-Amine Modified β-Cyclodextrin Catalyzed Green Synthesis of Pyrimidones and Its In Silico Study against ESBL E. coli Receptor. Preprints. https://doi.org/10.20944/preprints202312.2306.v2

Chicago/Turabian Style

Rajapriyan, M., Javed Masood Khan and Ayyiliath M Sajith. 2024 "Ethylene-Di-Amine Modified β-Cyclodextrin Catalyzed Green Synthesis of Pyrimidones and Its In Silico Study against ESBL E. coli Receptor" Preprints. https://doi.org/10.20944/preprints202312.2306.v2

Abstract

Modern organic synthesis is majorly focused on developing environmentally benign synthetic protocols by employing green chemistry principles. Accordingly, in our recent research work, we herein report the use of modified supramolecular host cyclodextrin as an effective solid based green catalyst for accessing structurally diverse and medicinally relevant pyrimidone architectures. The catalyst and the synthesized compounds 4 (a-r) were characterized using FT-IR, NMR and GC-Mass spectroscopy. Major highlights of the reported work include: atom economical process, extremely milder reaction conditions, operational simplicity, high isolated yields, and excellent catalyst turnover number. The molecular docking studies suggest that the compound 4n has the hydrogen bonding, hydrophobic and π-pair interactions with the active site of active sites of CXT M 15 receptor.

Keywords

Ethylene-di-amine modified β-CD; Multicomponent reaction; 3,4-dihydropyrimidin-2(1H)-ones DHPM derivatives; Solvent-free conditions; Reusability

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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