Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation

Laura Ansone
* ORCID logo ,
Vita Rovīte
,
Monta Brīvība
,
Lauma Jagare
,
Līva Pelcmane
,
Daniella Borisova
,
Anne Thews
,
Roland Leiminger
,
Jānis Kloviņš
* ORCID logo
Version 1 : Received: 18 December 2023 / Approved: 28 December 2023 / Online: 28 December 2023 (02:29:54 CET)

A peer-reviewed article of this Preprint also exists.

Ansone, L.; Rovite, V.; Brīvība, M.; Jagare, L.; Pelcmane, L.; Borisova, D.; Thews, A.; Leiminger, R.; Kloviņš, J. Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation. Int. J. Mol. Sci. 2024, 25, 1523. Ansone, L.; Rovite, V.; Brīvība, M.; Jagare, L.; Pelcmane, L.; Borisova, D.; Thews, A.; Leiminger, R.; Kloviņš, J. Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation. Int. J. Mol. Sci. 2024, 25, 1523.

Abstract

Long Covid or post-acute sequelae of SARS-CoV-2 infection (PASC) can manifest as long-term symptoms in multiple organ systems, including respiratory, cardiovascular, neurological, and metabolic systems. In patients with severe COVID-19, immune dysregulation is significant, and the relationship between metabolic regulation and immune response is of great interest in determining the pathophysiological mechanisms. We aimed to characterize the metabolomic footprint for recovering severe COVID-19 patients in three consecutive time points and compare metabolite levels to controls. Our findings add proof of dysregulated amino acid metabolism in the acute phase, and dyslipidemia, glycoprotein level alterations, and energy metabolism disturbances in severe COVID-19 patients 3-4 months post hospitalization.

Keywords

COVID-19; SARS-CoV-2; Post-acute sequelae of SARS-CoV-2; metabolomics; dyslipdemia; Nuclear magnetic resonance

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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