Version 1
: Received: 26 December 2023 / Approved: 27 December 2023 / Online: 27 December 2023 (05:18:32 CET)
How to cite:
Errede, M.; D’Amati, A.; Annese, T.; De Trizio, I.; Wälchli, T.; Girolamo, F.; Virgintino, D. Pericyte-Tunnelling Nanotube-Driven Angiogenesis and C-KIT Immunolocalization in Human Developing Brain and Glioblastoma. Preprints2023, 2023122049. https://doi.org/10.20944/preprints202312.2049.v1
Errede, M.; D’Amati, A.; Annese, T.; De Trizio, I.; Wälchli, T.; Girolamo, F.; Virgintino, D. Pericyte-Tunnelling Nanotube-Driven Angiogenesis and C-KIT Immunolocalization in Human Developing Brain and Glioblastoma. Preprints 2023, 2023122049. https://doi.org/10.20944/preprints202312.2049.v1
Errede, M.; D’Amati, A.; Annese, T.; De Trizio, I.; Wälchli, T.; Girolamo, F.; Virgintino, D. Pericyte-Tunnelling Nanotube-Driven Angiogenesis and C-KIT Immunolocalization in Human Developing Brain and Glioblastoma. Preprints2023, 2023122049. https://doi.org/10.20944/preprints202312.2049.v1
APA Style
Errede, M., D’Amati, A., Annese, T., De Trizio, I., Wälchli, T., Girolamo, F., & Virgintino, D. (2023). Pericyte-Tunnelling Nanotube-Driven Angiogenesis and C-KIT Immunolocalization in Human Developing Brain and Glioblastoma. Preprints. https://doi.org/10.20944/preprints202312.2049.v1
Chicago/Turabian Style
Errede, M., Francesco Girolamo and Daniela Virgintino. 2023 "Pericyte-Tunnelling Nanotube-Driven Angiogenesis and C-KIT Immunolocalization in Human Developing Brain and Glioblastoma" Preprints. https://doi.org/10.20944/preprints202312.2049.v1
Abstract
Pericyte and their tunnelling nanotubes (P-TNTs) have been described as involved in the early phases of angiogenesis in the human normal developing brain and glioblastoma, being a common feature of combined endothelium/pericyte vessel sprouts. Based on the few data available so far about this ‘alternative’ pericyte-TNT-driven mode of angiogenesis, whose precise function in vessel growth through vascular cells communication, has still to be determined, this study aims to cast light on the regulative molecules involved in this process, governed by intimate pericyte-endothelial interactions. After considering the existence of the sprout guiding pericyte and P-TNT, as shown by pioneering ultrastructural studies as well as by more recent observations with NG2/CD146 pericyte markers and basal lamina molecules, a step-by-step profile of the process has been suggested and an investigation undertaken on ‘unconventional’, pro-angiogenic ligand/receptor systems, that may have a role aside from the canonical pathways. In this context, a possible candidate worthy of investigation is the c-KIT receptor, a member of the tyrosine kinase family of proteins, which also includes the well-known VEGFR and PDGFR. According to the obtained results showing a primary localization of c-KIT on endothelial cells and pointing out a differential distribution of the receptor on normal vs glioblastoma vessels, it seems conceivable to propose the stem cell factor/c-KIT signaling as a key factor in pericyte-TNT-driven angiogenesis, advancing this alternative mode of angiogenesis and the c- KIT pathway as possible targets for devising effective antiangiogenic therapeutic strategies.
Keywords
c-KIT; tunnelling nanotubes; pericytes; angiogenesis; human brain; glioblastoma
Subject
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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