Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Unveiling Extramedullary Hematopoiesis: A Case Report Highlighting the Causes, Symptoms, and Management Strategies

Konstantinos Manganas
ORCID logo ,
Aikaterini Xydaki
,
Angeliki Kotsiafti
,
Olympia Papakonstantinou
,
Sophia Delicou
*
Version 1 : Received: 21 December 2023 / Approved: 24 December 2023 / Online: 25 December 2023 (08:15:21 CET)

A peer-reviewed article of this Preprint also exists.

Manganas, K.; Xydaki, A.; Kotsiafti, A.; Papakonstantinou, O.; Delicou, S. Unveiling Extramedullary Hematopoiesis: A Case Report Highlighting the Causes, Symptoms, and Management Strategies. Thalass. Rep. 2024, 14, 26-32. Manganas, K.; Xydaki, A.; Kotsiafti, A.; Papakonstantinou, O.; Delicou, S. Unveiling Extramedullary Hematopoiesis: A Case Report Highlighting the Causes, Symptoms, and Management Strategies. Thalass. Rep. 2024, 14, 26-32.

Abstract

Extramedullary hematopoiesis is a compensatory response in chronic hemolytic anemia, such as thalassemia, and can lead to spinal cord compression. This case report describes a 36-year-old woman with β-thalassemia who presented with lower extremity motor deficiency, pelvic paresthesia, and bladder dysfunction. The patient had a history of low back pain, bilateral lower limb weakness, and poor compliance with iron chelation therapy. MRI revealed compression of the spinal cord due to extramedullary hematopoiesis. Surgical intervention was not feasible, and the patient underwent hypertransfusion and iron chelation therapy. Neurological symptoms improved, but urinary retention persisted. The patient continues to receive iron chelation treatment and undergoes transfusions. Extramedullary hematopoiesis is a common complication in thalassemia and requires an individualized treatment approach.

Keywords

extramedullary hematopoiesis; chronic hemolytic anemia; thalassemia; blood transfusions; radiation therapy; surgical decompression; hydroxyurea therapy

Subject

Medicine and Pharmacology, Clinical Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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