Version 1
: Received: 11 December 2023 / Approved: 11 December 2023 / Online: 11 December 2023 (16:00:03 CET)
How to cite:
Arhire, A. I.; Papuc, T.; Ioacara, S.; Pircalabioru, G. G.; Fica, S. Correlations between Intestinal Dysbiosis and the Onset of Type 1 Diabetes in a Group of Pediatric Patients. Preprints2023, 2023120720. https://doi.org/10.20944/preprints202312.0720.v1
Arhire, A. I.; Papuc, T.; Ioacara, S.; Pircalabioru, G. G.; Fica, S. Correlations between Intestinal Dysbiosis and the Onset of Type 1 Diabetes in a Group of Pediatric Patients. Preprints 2023, 2023120720. https://doi.org/10.20944/preprints202312.0720.v1
Arhire, A. I.; Papuc, T.; Ioacara, S.; Pircalabioru, G. G.; Fica, S. Correlations between Intestinal Dysbiosis and the Onset of Type 1 Diabetes in a Group of Pediatric Patients. Preprints2023, 2023120720. https://doi.org/10.20944/preprints202312.0720.v1
APA Style
Arhire, A. I., Papuc, T., Ioacara, S., Pircalabioru, G. G., & Fica, S. (2023). Correlations between Intestinal Dysbiosis and the Onset of Type 1 Diabetes in a Group of Pediatric Patients. Preprints. https://doi.org/10.20944/preprints202312.0720.v1
Chicago/Turabian Style
Arhire, A. I., Gratiela Gradisteanu Pircalabioru and Simona Fica. 2023 "Correlations between Intestinal Dysbiosis and the Onset of Type 1 Diabetes in a Group of Pediatric Patients" Preprints. https://doi.org/10.20944/preprints202312.0720.v1
Abstract
Background: Over the past years, there has been a rise in the incidence of type 1 diabetes, partic-ularly among younger individuals. This concerning trend has prompted investigations into po-tential contributing factors, with intestinal dysbiosis emerging as a likely culprit for the escalating annual rates of the disease; (2) Methods: We conducted a retrospective ecologic correlational study involving 37 children from the southern region of Romania between 2019-2021. All participants were within the first six months following the onset of the disease; (3) Results: In the microbiota of the patients we observed a dysbiosis marked by an overabundance of bacteria (Clostridium coccoides, Faecalibacterium, Bacterioides, Enterobacteriaceae) and fungi, compared to the healthy control group. The Spearman correlation revealed a positive association between the presence of Bacteroides (p=0.0442), Butyricicoccus (p=0.0164), and Clostridium leptum (p=0.0023) with recent diabetes onset. Furthermore, a significant correlation was observed between younger age at onset and the pres-ence of Butyricicoccus (p=0.019). The use of antibiotics in the month preceding admission was linked to the presence of fungi in the microbiota (Candida, p=0.0442); (4) Conclusions: The dysbiosis of Romanian type 1 diabetes children correlates with inflammation, more severe onset of the disease and other au-toimmune diseases.
Keywords
microbiota; dysbiosis; type 1 diabetes; autoimmunity
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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