Version 1
: Received: 7 December 2023 / Approved: 8 December 2023 / Online: 8 December 2023 (10:09:23 CET)
How to cite:
Öztelcan Gündüz, B.; Dinleyici, E.C.; Tekin, N.A.; Çolak, Ö.; Akşit, A.M. Exploring PTX3 as a Diagnostic and Prognostic Marker in Fetal Inflammatory Response Syndrome in Newborns: A Prospective Study. Preprints2023, 2023120589. https://doi.org/10.20944/preprints202312.0589.v1
Öztelcan Gündüz, B.; Dinleyici, E.C.; Tekin, N.A.; Çolak, Ö.; Akşit, A.M. Exploring PTX3 as a Diagnostic and Prognostic Marker in Fetal Inflammatory Response Syndrome in Newborns: A Prospective Study. Preprints 2023, 2023120589. https://doi.org/10.20944/preprints202312.0589.v1
Öztelcan Gündüz, B.; Dinleyici, E.C.; Tekin, N.A.; Çolak, Ö.; Akşit, A.M. Exploring PTX3 as a Diagnostic and Prognostic Marker in Fetal Inflammatory Response Syndrome in Newborns: A Prospective Study. Preprints2023, 2023120589. https://doi.org/10.20944/preprints202312.0589.v1
APA Style
Öztelcan Gündüz, B., Dinleyici, E.C., Tekin, N.A., Çolak, Ö., & Akşit, A.M. (2023). Exploring PTX3 as a Diagnostic and Prognostic Marker in Fetal Inflammatory Response Syndrome in Newborns: A Prospective Study. Preprints. https://doi.org/10.20944/preprints202312.0589.v1
Chicago/Turabian Style
Öztelcan Gündüz, B., Ömer Çolak and Arif Mehmet Akşit. 2023 "Exploring PTX3 as a Diagnostic and Prognostic Marker in Fetal Inflammatory Response Syndrome in Newborns: A Prospective Study" Preprints. https://doi.org/10.20944/preprints202312.0589.v1
Abstract
Abstract
Background
Pentraxin 3 (PTX3), an acute-phase protein associated with innate immunity, serves as a promising biomarker with diagnostic and prognostic value in preterm newborns. We aimed to investigate the relationship between PTX3 levels in neonates diagnosed with FIRS and early postnatal outcomes.
Material and methods
The study was designed as a prospective study. A total of 62 infants, 28–36 weeks of gestational age, were enrolled. During their neonatal intensive care unit (NICU) stay, the patients' mortality and morbidity outcomes were recorded and monitored. PTX3 concentrations were studied in plasma in the maternal peripheral blood and umbilical/peripheral veins of neonates. The relationship between PTX3 concentrations and neonatal outcomes was investigated using non-parametric tests, regression analysis, and receiver operating characteristic (ROC) analysis.
Results
PTX3 levels in cord blood and peripheral blood samples of neonates were significantly associated with clinical conditions such as respiratory distress syndrome (RDS) (p = 0.022), sepsis (p = 0.001), neonatal pneumonia (p = 0.016), and FIRS (p = 0.001). In infants with FIRS, the increase in PTX3 was statistically significant (p = 0.013), with an OR of 1.131 (95% CI 1.026–1.246). The PTX3 level had a cutoff value >4.45 (p<0.001) for predicting FIRS with an AUC of 0.759, 76.9% sensitivity (95% CI 56.4–91), and 63.9% specificity (95% CI 46.2–79.2).
Conclusions
This study demonstrates that PTX3 shows potential as a sensitive and specific biomarker for the early diagnosis of FIRS in preterm newborns. PTX3 levels were significantly associated with clinical outcomes such as RDS, sepsis, neonatal pneumonia, and FIRS.
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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