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Association of GLIM-Defined Malnutrition in Kidney Dysfunction With Increased All-Cause Mortality from Infections in Hospitalized Older Adults: A Retrospective Cohort Study
Yamaguchi, M.; Sugiyama, H.; Akimasa, A.; Kamiya, K.; Kitamura, F.; Kinashi, H.; Katsuno, T.; Bannno, S.; Ishimoto, T.; Imaizumi, T.; Maeda, K.; Ishida, Y.; Mori, N.; Ito, Y. Association of GLIM-Defined Malnutrition in Kidney Dysfunction With Increased All-Cause Mortality from Infections in Hospitalized Older Adults: A Retrospective Cohort Study. Preprints2023, 2023120436. https://doi.org/10.20944/preprints202312.0436.v1
APA Style
Yamaguchi, M., Sugiyama, H., Akimasa, A., Kamiya, K., Kitamura, F., Kinashi, H., Katsuno, T., Bannno, S., Ishimoto, T., Imaizumi, T., Maeda, K., Ishida, Y., Mori, N., & Ito, Y. (2023). Association of GLIM-Defined Malnutrition in Kidney Dysfunction With Increased All-Cause Mortality from Infections in Hospitalized Older Adults: A Retrospective Cohort Study. Preprints. https://doi.org/10.20944/preprints202312.0436.v1
Chicago/Turabian Style
Yamaguchi, M., Naoharu Mori and Yasuhiko Ito. 2023 "Association of GLIM-Defined Malnutrition in Kidney Dysfunction With Increased All-Cause Mortality from Infections in Hospitalized Older Adults: A Retrospective Cohort Study" Preprints. https://doi.org/10.20944/preprints202312.0436.v1
Abstract
Worldwide, among older adults, infection is the leading mortality cause; chronic nutritional deficits confer significant mortality risk and increase healthcare costs. The association of the Global Leadership Initiative on Malnutrition (GLIM)-defined malnutrition with infection-related mortality, especially with renal dysfunction in older patients, remains unevaluated. In older patients hospitalized with infection, stratified by renal function, we investigated the association of malnutrition severity with mortality. This single-center, retrospective cohort study of 1220 participants (age ≥65 years) admitted to Aichi Medical University from 2019 to 2020 used a multivariate Cox proportional hazards model to determine the association of GLIM-defined nutritional status (no, moderate, or severe malnutrition) with all-cause mortality. Compared to no malnutrition, moderate and severe malnutrition conferred significantly higher mortality (adjusted hazard ratio [confidence interval ]: 1.00 [reference], 1.76 [1.28-2.42], and 2.44 [1.78-3.33], respectively), with the highest all-cause mortality in malnutrition with a low estimated glomerular filtration rate (eGFR <30 mL/min/1.73m2; 7.35 [4.57-11.8]) compared to no malnutrition and normal eGFR (≥60 mL/min/1.73m2). GLIM-defined malnutrition confers higher all-cause mortality risk in older adults with infection, especially those with renal dysfunction. This information enables the identification of high-risk older patients with infection and targeted clinical management of those with malnutrition, renal dysfunction, and infection.
Keywords
infection; Global Leadership Initiative on Malnutrition; malnutrition; mortality
Subject
Medicine and Pharmacology, Internal Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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