Version 1
: Received: 30 November 2023 / Approved: 1 December 2023 / Online: 1 December 2023 (05:29:59 CET)
How to cite:
Beihaghia, M.; Sahebi, R.; Beihaghi, M.R.; Tehrani, H.; Attaran Dowom, S.; Khosravi neissiani, R.; Janati, Z. Development of Skin Diseases Treatment based on Exosome Derived from Plants, Humans, Medicinal Algae and Fungi. Preprints2023, 2023120021. https://doi.org/10.20944/preprints202312.0021.v1
Beihaghia, M.; Sahebi, R.; Beihaghi, M.R.; Tehrani, H.; Attaran Dowom, S.; Khosravi neissiani, R.; Janati, Z. Development of Skin Diseases Treatment based on Exosome Derived from Plants, Humans, Medicinal Algae and Fungi. Preprints 2023, 2023120021. https://doi.org/10.20944/preprints202312.0021.v1
Beihaghia, M.; Sahebi, R.; Beihaghi, M.R.; Tehrani, H.; Attaran Dowom, S.; Khosravi neissiani, R.; Janati, Z. Development of Skin Diseases Treatment based on Exosome Derived from Plants, Humans, Medicinal Algae and Fungi. Preprints2023, 2023120021. https://doi.org/10.20944/preprints202312.0021.v1
APA Style
Beihaghia, M., Sahebi, R., Beihaghi, M.R., Tehrani, H., Attaran Dowom, S., Khosravi neissiani, R., & Janati, Z. (2023). Development of Skin Diseases Treatment based on Exosome Derived from Plants, Humans, Medicinal Algae and Fungi. Preprints. https://doi.org/10.20944/preprints202312.0021.v1
Chicago/Turabian Style
Beihaghia, M., Rahele Khosravi neissiani and Zahra Janati. 2023 "Development of Skin Diseases Treatment based on Exosome Derived from Plants, Humans, Medicinal Algae and Fungi" Preprints. https://doi.org/10.20944/preprints202312.0021.v1
Abstract
Annually, millions of people worldwide are affected by skin diseases, and current therapeutic approaches have limited efficacy. Advances in the treatment of exosomes have led to the development of new therapeutic methods that hold promising potential for improving the treatment options for skin diseases. The aim of this study is to produce pharmaceutical and cosmetic compounds based on exosomes for the treatment of skin conditions such as eczema, pigmentation disorders, skin sagging and aging, cellular skin regeneration, increased skin moisture, and prevention of skin shedding, among others. This study examines the effects of exosomes derived from plants, humans, medicinal algae, and fungi to treat skin diseases. Spectrophotometric analysis reveals the presence of nucleic acids and proteins in exosome samples, indicating their cargo composition. TEM micrographs demonstrate that the exosome isolation process preserves the integrity of the membrane and the crucial spherical structure for their functionality. DLS analysis confirms that isolated exosomes have a size similar to typical exosome dimensions. MTT assays indicate concentration-dependent cytotoxic effects of exosomes on skin cells, with a calculated IC50 representing a significant decrease in cell viability. Real-time PCR shows higher gene expression levels of collagen I and collagen III, indicating the potential of exosomes to enhance collagen synthesis. Tyrosinase enzyme expression analysis demonstrates the influence of exosome treatments on pathways related to melanin production. The use of exosomes derived from various sources provides a promising platform for developing new drugs in the treatment of skin diseases. Additionally, exosomes can be utilized in the treatment of autoimmune diseases and cancer, transforming them into a hopeful field of research. Plant-derived exosomes are environmentally friendly and can serve as the next generation of drug delivery systems for treating various diseases.
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
