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Computation Analysis of Histone Deacetylases With Curcumin
Version 1
: Received: 26 November 2023 / Approved: 27 November 2023 / Online: 27 November 2023 (09:08:47 CET)
How to cite: FERRARI, I.V. Computation Analysis of Histone Deacetylases With Curcumin. Preprints 2023, 2023111666. https://doi.org/10.20944/preprints202311.1666.v1 FERRARI, I.V. Computation Analysis of Histone Deacetylases With Curcumin. Preprints 2023, 2023111666. https://doi.org/10.20944/preprints202311.1666.v1
Abstract
The assessment of Histone deacetylases in conjunction with Curcumin, conducted through the Mcule Database employing the Autodock Vina algorithm, involves an examination of molecular interactions. This analysis includes the calculation of binding energies, revealing the strength and stability of the interactions between Curcumin and various Histone deacetylase targets. The comparison encompasses diverse aspects such as binding energies, specific binding sites, interactions across different targets, structural details, and potential implications for biological activity. The results imply that Curcumin shows heightened affinity for Histone deacetylase 4 in comparison to other investigated histone deacetylases.
Keywords
HDACs, curcumin; molecular docking
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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