PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
In-Vitro Activity of N, N-diethyldithiocarbamate against Ureaplasma urealyticum and Ureaplasma parvum Isolated from Women with Infections of the Urogenital Tract
Biernat-Sudolska, M.; Rojek-Zakrzewska, D.; Drożdż, K.; Bilska-Wilkosz, A. Antimicrobial Activity of N,N-Diethyldithiocarbamate against Ureaplasma parvum and Ureaplasma urealyticum. Int. J. Mol. Sci.2024, 25, 40.
Biernat-Sudolska, M.; Rojek-Zakrzewska, D.; Drożdż, K.; Bilska-Wilkosz, A. Antimicrobial Activity of N,N-Diethyldithiocarbamate against Ureaplasma parvum and Ureaplasma urealyticum. Int. J. Mol. Sci. 2024, 25, 40.
Biernat-Sudolska, M.; Rojek-Zakrzewska, D.; Drożdż, K.; Bilska-Wilkosz, A. Antimicrobial Activity of N,N-Diethyldithiocarbamate against Ureaplasma parvum and Ureaplasma urealyticum. Int. J. Mol. Sci.2024, 25, 40.
Biernat-Sudolska, M.; Rojek-Zakrzewska, D.; Drożdż, K.; Bilska-Wilkosz, A. Antimicrobial Activity of N,N-Diethyldithiocarbamate against Ureaplasma parvum and Ureaplasma urealyticum. Int. J. Mol. Sci. 2024, 25, 40.
Abstract
Ureaplasma species (Ureaplasma spp.) are commonly found as commensals in the human urogenital tracts , but their overgrowth can lead to infection in the urogenital tract and at distal sites. Treatment of Ureaplasma spp. infections is difficult. The lack of a cell wall confers resistance to all β-lactam and glycopeptide antibiotics whereas the lack of de novo synthesis of folic acid makes them resistant to sulfonamides and diaminopyrimidines. Thus, there is a need to search for new drugs effective against these bacteria.
In the presented studies, the effect of N,N-diethyldithiocarbamate (DDC) at a concentration of 2 µg/ml, 20 µg/ml and 200 µg/ml on the growth and survival of Ureaplasma urealyticum and Ureaplasma parvum was tested. Our results indicated that all DDC concentrations used showed both bacteriostatic and bactericidal activity against both tested strains
In brief, for the first time we showed the bacteriostatic and bactericidal activity of DDC against Ureplasma urealyticum and Ureaplasma parvum. Based on literature data, we conclude that this DDC activity is related to the inhibition of urease activity, which is an indispensable enzyme for these bacteria. Further research is needed and the results obtained in the present study should be verified in in vivo models of infection.
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
