Bagińska, J.; Kirejczyk, J.K.; Korzeniecka-Kozerska, A. Evaluation of Urinary L-FABP as a Tubular Damage Marker in Pediatric Neurogenic Bladder—A Pilot Study. J. Clin. Med.2024, 13, 736.
Bagińska, J.; Kirejczyk, J.K.; Korzeniecka-Kozerska, A. Evaluation of Urinary L-FABP as a Tubular Damage Marker in Pediatric Neurogenic Bladder—A Pilot Study. J. Clin. Med. 2024, 13, 736.
Bagińska, J.; Kirejczyk, J.K.; Korzeniecka-Kozerska, A. Evaluation of Urinary L-FABP as a Tubular Damage Marker in Pediatric Neurogenic Bladder—A Pilot Study. J. Clin. Med.2024, 13, 736.
Bagińska, J.; Kirejczyk, J.K.; Korzeniecka-Kozerska, A. Evaluation of Urinary L-FABP as a Tubular Damage Marker in Pediatric Neurogenic Bladder—A Pilot Study. J. Clin. Med. 2024, 13, 736.
Abstract
The article aims to find potential biomarker for the detection of tubular damage in pediatric neurogenic bladder (NB) by investigating urinary levels of liver-type fatty acid-binding protein (uL-FABP). This prospective analysis was conducted on two groups: 42 children with NB and 18 healthy children. The uL-FABP concentrations were measured using ELISA methods. The children’s medical charts were analyzed to determine age, sex, anthropometric measurements, activity assessment using Hoffer’s scale and renal function parameters. The results revealed that the uL-FABP/creatinine ratio was higher in the studied group compared with the reference group. A significant positive correlation between uL-FABP and proteinuria was found. Children with a history of vesicoureteral reflux (VUR) tended to have elevated uL-FABP. In conclusion, uL-FABP may be considered a potential tubular damage biomarker in children with NB. Proteinuria and history of VUR may be the factors influencing uL-FABP.
Keywords
neurogenic bladder; L-FABP; proteinuria
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
