Version 1
: Received: 9 October 2023 / Approved: 16 November 2023 / Online: 17 November 2023 (02:35:39 CET)
How to cite:
Letonja, J.; Petrovič, D. Review of microRNAs and lncRNAs in atherosclerosis, diabetes, and other inflammatory conditions. Preprints2023, 2023111097. https://doi.org/10.20944/preprints202311.1097.v1
Letonja, J.; Petrovič, D. Review of microRNAs and lncRNAs in atherosclerosis, diabetes, and other inflammatory conditions. Preprints 2023, 2023111097. https://doi.org/10.20944/preprints202311.1097.v1
Letonja, J.; Petrovič, D. Review of microRNAs and lncRNAs in atherosclerosis, diabetes, and other inflammatory conditions. Preprints2023, 2023111097. https://doi.org/10.20944/preprints202311.1097.v1
APA Style
Letonja, J., & Petrovič, D. (2023). Review of microRNAs and lncRNAs in atherosclerosis, diabetes, and other inflammatory conditions. Preprints. https://doi.org/10.20944/preprints202311.1097.v1
Chicago/Turabian Style
Letonja, J. and Danijel Petrovič. 2023 "Review of microRNAs and lncRNAs in atherosclerosis, diabetes, and other inflammatory conditions" Preprints. https://doi.org/10.20944/preprints202311.1097.v1
Abstract
It is generally accepted that atherosclerosis is a chronic inflammatory disease. The link between atherosclerosis and other inflammatory diseases such as psoriasis, type 2 diabetes mellitus (T2DM), and rheumatoid arthritis (RA) via metabolic, inflammatory, and immunoregulatory pathways is well established. The aim of our review was to summarize the associations between selected microRNAs (miRs) and long non-coding RNAs (lncRNAs) and atherosclerosis, psoriasis, T2DM, and RA. MicroRNAs are short noncoding RNA molecules involved in cell signaling, intracellular communication, and gene expression. We reviewed the role of miR-146a, miR-210, miR-143, miR-223, miR-126, miR-21, miR-155, miR-145, miR-200, miR-133, miR-135, miR-221, miR-424, and let-7 in atherosclerosis, psoriasis, T2DM, and RA. LncRNAs are RNA transcripts longer than 200 nucleotides that are involved in cellular processes such as apoptosis, metabolism, inflammation, cell differentiation, and proliferation. We evaluated the role of lncRNA-H19, lncRNA-MEG3, lncRNA-UCA1, and lncRNA-XIST in atherosclerosis and psoriasis, T2DM, and RA. Extracellular vesicles (EVs) are a method of intracellular signal transduction. Their function depends on surface expression, cargo, and the cell from which they originate.
Keywords
Atherosclerosis; psoriasis; microRNA; extracellular vesicles; long non-coding RNA
Subject
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
