PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Relationship between Human Milk Oligosaccharide Profiles and Weight Growth Indicators of Indonesian Infants Aged 0–4 Months: A Prospective Longitudinal Study
Version 1
: Received: 15 November 2023 / Approved: 16 November 2023 / Online: 16 November 2023 (10:31:03 CET)
How to cite:
Sudarma, V.; Hegar, B.; Sunardi, D.; Marzuki, N.S.; Munasir, Z.; Asmarinah, A.; Hidayat, A. Relationship between Human Milk Oligosaccharide Profiles and Weight Growth Indicators of Indonesian Infants Aged 0–4 Months: A Prospective Longitudinal Study. Preprints2023, 2023111059. https://doi.org/10.20944/preprints202311.1059.v1
Sudarma, V.; Hegar, B.; Sunardi, D.; Marzuki, N.S.; Munasir, Z.; Asmarinah, A.; Hidayat, A. Relationship between Human Milk Oligosaccharide Profiles and Weight Growth Indicators of Indonesian Infants Aged 0–4 Months: A Prospective Longitudinal Study. Preprints 2023, 2023111059. https://doi.org/10.20944/preprints202311.1059.v1
Sudarma, V.; Hegar, B.; Sunardi, D.; Marzuki, N.S.; Munasir, Z.; Asmarinah, A.; Hidayat, A. Relationship between Human Milk Oligosaccharide Profiles and Weight Growth Indicators of Indonesian Infants Aged 0–4 Months: A Prospective Longitudinal Study. Preprints2023, 2023111059. https://doi.org/10.20944/preprints202311.1059.v1
APA Style
Sudarma, V., Hegar, B., Sunardi, D., Marzuki, N.S., Munasir, Z., Asmarinah, A., & Hidayat, A. (2023). Relationship between Human Milk Oligosaccharide Profiles and Weight Growth Indicators of Indonesian Infants Aged 0–4 Months: A Prospective Longitudinal Study. Preprints. https://doi.org/10.20944/preprints202311.1059.v1
Chicago/Turabian Style
Sudarma, V., Asmarinah Asmarinah and Adi Hidayat. 2023 "Relationship between Human Milk Oligosaccharide Profiles and Weight Growth Indicators of Indonesian Infants Aged 0–4 Months: A Prospective Longitudinal Study" Preprints. https://doi.org/10.20944/preprints202311.1059.v1
Abstract
Studies show Human Milk Oligosaccharides (HMOs) influence on infant growth were conflicted. This study aims to determine the relationship between HMO profiles and weight growth indicators of infants ages 0-4 months in Indonesia. A prospective longitudinal study was conducted among 120 mother-infant pairs aged 0 – 4 months from the hospital and Public Health Center in Jakarta between August 2021 – May 2022. The gene analysis for the Secretor and Lewis status of the mother were performed by using targeted Next Generation Sequencing (NGS) and Sanger at baseline. The HMO profiles (2'FL, LNFP I, LNT, LNnT, 3'SL, and 6'SL), breast milk calories, and fat were examined at 0, 2, and 4 months. Weight for age z-score, weight for length z-score, infection episode, and mother's body mass index were examined every month. Data were analyzed using Pearson or Spearman correlation test (correlation coefficient), general linear model for repeated measures ANOVA test and Friedman test (mean difference between and within groups, respectively) and logistic regression unadjusted OR (association between dependent and independent variables), with a p-value <0.05 considered statistically significant. Infants' weight velocities were higher among high LNT and 3'SL levels in the second month, and in high 2'FL and LNFP I mothers in the fourth month. HMO profile (2’FL, LNFP I, and LNT) of lactating mothers have a positive relationship with weight growth indicators, and innovative interventions to enhance HMO concentration among mothers should be considered as one of the ways to improve infant growth.
Keywords
human milk oligosaccharides; growth indicator; secretor status
Subject
Medicine and Pharmacology, Dietetics and Nutrition
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
