Version 1
: Received: 8 November 2023 / Approved: 9 November 2023 / Online: 9 November 2023 (07:18:42 CET)
How to cite:
Patel, M.; Andharia, D.; Shah, A.; Shah, H.; Patel, D.; Desai, D. The Usefulness of Magnetic Resonance Imaging(MRI) for Detection of Appendicitis – a Diagnostic Test Accuracy Meta-Analysis. Preprints2023, 2023110604. https://doi.org/10.20944/preprints202311.0604.v1
Patel, M.; Andharia, D.; Shah, A.; Shah, H.; Patel, D.; Desai, D. The Usefulness of Magnetic Resonance Imaging(MRI) for Detection of Appendicitis – a Diagnostic Test Accuracy Meta-Analysis. Preprints 2023, 2023110604. https://doi.org/10.20944/preprints202311.0604.v1
Patel, M.; Andharia, D.; Shah, A.; Shah, H.; Patel, D.; Desai, D. The Usefulness of Magnetic Resonance Imaging(MRI) for Detection of Appendicitis – a Diagnostic Test Accuracy Meta-Analysis. Preprints2023, 2023110604. https://doi.org/10.20944/preprints202311.0604.v1
APA Style
Patel, M., Andharia, D., Shah, A., Shah, H., Patel, D., & Desai, D. (2023). The Usefulness of Magnetic Resonance Imaging(MRI) for Detection of Appendicitis – a Diagnostic Test Accuracy Meta-Analysis. Preprints. https://doi.org/10.20944/preprints202311.0604.v1
Chicago/Turabian Style
Patel, M., Dev Patel and Dev Desai. 2023 "The Usefulness of Magnetic Resonance Imaging(MRI) for Detection of Appendicitis – a Diagnostic Test Accuracy Meta-Analysis" Preprints. https://doi.org/10.20944/preprints202311.0604.v1
Abstract
Background: Appendicitis is a common cause of emergency department visits and appendectomies in the US, with 250,000 appendectomies performed annually. Current diagnostic methods, such as clinical findings, lead to inaccuracies and missed diagnoses, increasing morbidity and mortality. The only solution is surgery, but current hematological tests are not reliable and may lead to unnecessary surgery if the underlying etiology is self-limiting or requires medical treatment. This study explores the role of MRI as a diagnostic modality that can replace US/CT and supplement traditional clinical diagnostic signs while avoiding ionizing radiation and intravenous contrast medium. The purpose of this meta-analysis is to determine the accuracy of MRI as a diagnostic modality in diagnosing appendicitis, addressing concerns about diagnostic modalities and their adverse effects, and addressing the necessity and success of relevant interventions. Methods: Medical literature was comprehensively searched and reviewed without restrictions to particular study designs, or publication dates using PubMed, Cochrane Library, and Google Scholar databases for all relevant literature formulated in English. The extraction of necessary data proceeded after specific inclusion and exclusion criteria were applied. Meta Analysis was performed for 5206 patients, with 35 RCTs being selected. Analysis was done using the QualSyst tool, wherein two writers independently assessed the caliber of each study as well as the use of the Cochrane tool for bias risk apprehension. The statistical software packages RevMan (Review Manager, version 5.3), SPSS (Statistical Package for the Social Sciences, version 20), and Excel in Stata 14 were used to perform the statistical analyses along with other analytical software. Results: MRI had an overall sensitivity of over 95%, an overall specificity of 94.2% with a PPV of 0.875 in comparison to CT scan in the diagnosis and intervention regarding appendicitis. Conclusion: These findings strongly suggest that MRI is a reasonable alternative to CT for the diagnosis of appendicitis in hospitals with appropriate access to this technology for reasons about accuracy, reliability, and reproducibility as well as addressing safety concerns.
Keywords
MRI; US; CT; Appendicitis
Subject
Medicine and Pharmacology, Surgery
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
