Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Advantages of Long Wavelength Photosensitizer meso-Tetra(3-Pyridyl) Bacteriochlorin in Therapy of Bulky Tumors

Ekaterina A. Plotnikova
ORCID logo ,
Elena Nemtsova
* ,
Maxim A. Abakumov
ORCID logo ,
Andrei Pankratov
,
Peter Shegai
,
Andrey Kaprin
Version 1 : Received: 8 November 2023 / Approved: 9 November 2023 / Online: 9 November 2023 (07:49:35 CET)

A peer-reviewed article of this Preprint also exists.

Plotnikova, E.; Nemtsova, E.; Abakumov, M.; Suvorov, N.; Pankratov, A.; Shegai, P.; Kaprin, A. Advantages of Long-Wavelength Photosensitizer meso-Tetra(3-pyridyl) Bacteriochlorin in the Therapy of Bulky Tumors. Pharmaceuticals 2023, 16, 1708. Plotnikova, E.; Nemtsova, E.; Abakumov, M.; Suvorov, N.; Pankratov, A.; Shegai, P.; Kaprin, A. Advantages of Long-Wavelength Photosensitizer meso-Tetra(3-pyridyl) Bacteriochlorin in the Therapy of Bulky Tumors. Pharmaceuticals 2023, 16, 1708.

Abstract

The research presents a novel synthetic photosensitizer for photodynamic therapy (PDT) of malignant tumors - meso-tetra(3-pyridyl) bacteriochlorin, which absorbs at 747 nm (in the long-wavelength region of the spectrum) and is stable when stored in the dark. H2Py4BC demonstrates pronounced photoinduced activity in vitro against tumor cells of various genesis (IC50 varies from 21 to 68 nM for НЕр2, EJ, S37, CТ26, and LLC cultured cells) and provides in vivo pronounced antitumor efficacy in the treatment of mice bearing small or large S37, Colo26, and LLC metastatic tumors, as well as in the treatment of rats bearing RS-1 liver cholangioma. As a result, total regress of primary tumor nodules and cure of 40 to 100% of the animals were proved by the experiment criteria, MRI, and histological analysis. Meso-tetra(3-pyridyl) bacteriochlorin quickly penetrates and accumulates in the tumor tissue and internal organs of mice, and after 24 hours 80% of the dye is excreted from skin as well as 87% - 92% from liver, kidneys, and spleen.

Keywords

photodynamic therapy; photosensitizer; bacteriochlorins; photocytotoxicity; photoinduced antitumor activity; cell; tissue; tumor

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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